RGD Reference Report - Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats. - Rat Genome Database

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Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.

Authors: Tachibana, M  Lu, L  Hiai, H  Tamura, A  Matsushima, Y  Shisa, H 
Citation: Tachibana M, etal., Exp Anim. 2006 Apr;55(2):91-5.
RGD ID: 1625009
Pubmed: (View Article at PubMed) PMID:16651691

Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.



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Mammalian Phenotype

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Strains with Phenominer Data Strains with phenominer data
LE/Stm F344/Stm

Objects Annotated

QTLs
Teswt1  (Testicular weight QTL 1)
Teswt2  (Testicular weight QTL 2)

Objects referenced in this article
Strain FXLE/Stm null Rattus norvegicus

Additional Information