RGD Reference Report - Evidence for glucose-6-phosphate transport in rat liver microsomes. - Rat Genome Database

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Evidence for glucose-6-phosphate transport in rat liver microsomes.

Authors: Gerin, I  Van Schaftingen, E 
Citation: Gerin I and Van Schaftingen E, FEBS Lett. 2002 Apr 24;517(1-3):257-60.
RGD ID: 1624965
Pubmed: PMID:12062448   (View Abstract at PubMed)

The existence of glucose-6-phosphate transport across the liver microsomal membrane is still controversial. In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate. S3483 also inhibited the conversion of glucose-6-phosphate to 6-phosphogluconate occurring inside microsomes in the presence of electron acceptors (NADP or metyrapone). These data indicate that liver microsomal membranes contain a reversible glucose-6-phosphate transporter, which furnishes substrate not only to glucose-6-phosphatase, but also to hexose-6-phosphate dehydrogenase.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc37a4Ratglucose-6-phosphate transport  IMP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc37a4Ratglucose-6-phosphate transmembrane transporter activity  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc37a4  (solute carrier family 37 member 4)


Additional Information