RGD Reference Report - Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. - Rat Genome Database

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Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.

Authors: Duivenvoorden, I  Teusink, B  Rensen, PC  Romijn, JA  Havekes, LM  Voshol, PJ 
Citation: Duivenvoorden I, etal., Diabetes. 2005 Mar;54(3):664-71.
RGD ID: 1601226
Pubmed: PMID:15734841   (View Abstract at PubMed)

Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates the development of obesity and consequently insulin resistance. Apoc3(-/-) mice and wild-type littermates were fed a high-fat (46 energy %) diet for 20 weeks. After 20 weeks of high-fat feeding, apoc3(-/-) mice showed decreased plasma triglyceride levels (0.11 +/- 0.02 vs. 0.29 +/- 0.04 mmol, P < 0.05) and were more obese (42.8 +/- 3.2 vs. 35.2 +/- 3.3 g; P < 0.05) compared with wild-type littermates. This increase in body weight was entirely explained by increased body lipid mass (16.2 +/- 5.9 vs. 10.0 +/- 1.8 g; P < 0.05). LPL-dependent uptake of triglyceride-derived fatty acids by adipose tissue was significantly higher in apoc3(-/-) mice. LPL-independent uptake of albumin-bound fatty acids did not differ. It is interesting that whole-body insulin sensitivity using hyperinsulinemic-euglycemic clamps was decreased by 43% and that suppression of endogenous glucose production was decreased by 25% in apoc3(-/-) mice compared with control mice. Absence of apoC3, the natural LPL inhibitor, enhances fatty acid uptake from plasma triglycerides in adipose tissue, which leads to higher susceptibility to diet-induced obesity followed by more severe development of insulin resistance. Therefore, apoC3 is a potential target for treatment of obesity and insulin resistance.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOC3HumanInsulin Resistance susceptibilityISOApoc3 (Mus musculus) RGD 
Apoc3RatInsulin Resistance susceptibilityISOApoc3 (Mus musculus) RGD 
Apoc3MouseInsulin Resistance susceptibilityIAGP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoc3  (apolipoprotein C3)

Genes (Mus musculus)
Apoc3  (apolipoprotein C-III)

Genes (Homo sapiens)
APOC3  (apolipoprotein C3)


Additional Information