RGD Reference Report - Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats. - Rat Genome Database

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Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats.

Authors: Li, F  Lim, CK  Peters, TJ 
Citation: Li F, etal., Biomed Chromatogr. 1990 Nov;4(6):253-6.
RGD ID: 1600959
Pubmed: PMID:2289051   (View Abstract at PubMed)
DOI: DOI:10.1002/bmc.1130040610   (Journal Full-text)

The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron-overloaded and acutely or chronically ethanol-treated rats were assayed by high performance liquid chromatographic methods. Decreased coproporphyrinogen oxidase activity was found in chronically carbonyliron-fed rats while the activities of protoporphyrinogen oxidase and ferrochelatase remained unchanged. Coproporphyrinogen oxidase and protoporphyrinogen oxidase activities in both chronically and acutely ethanol-treated animals were not significantly different from controls. In chronically ethanol-fed rats normal ferrochelatase activity was found.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CpoxRatresponse to iron ion  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cpox  (coproporphyrinogen oxidase)


Additional Information