RGD Reference Report - The expression of CD59 in experimental allergic neuritis. - Rat Genome Database

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The expression of CD59 in experimental allergic neuritis.

Authors: Vedeler, CA  Conti, G  Fujioka, T  Scarpini, E  Rostami, A 
Citation: Vedeler CA, etal., J Neurol Sci. 1999 Jun 1;165(2):154-9.
RGD ID: 1600494
Pubmed: PMID:10450801   (View Abstract at PubMed)

Complement is implicated as an effector in inflammatory demyelination occurring in Guillain-Barre syndrome (GBS) and in experimental allergic neuritis (EAN). CD59, a potent complement regulatory protein that inhibits the formation of the terminal cytolytic membrane attack complex (MAC), is expressed on human and rat Schwann cells. In EAN the expression of CD59 was increased on Schwann cells during demyelination and axonal degeneration, evaluated by immunostaining of nerve sections and teased fibres. Mac-1 (CD11b) positive leukocytes were localized close to the Schwann cells showing enhanced CD59 staining. The increased CD59 expression in EAN could therefore be due to the release of cytokines or other immunoregulatory molecules from the inflammatory cells. However, interferon gamma (IFN-gamma) or tumor necrosis factor alfa (TNF-alpha) did not upregulate the expression of CD59 on rat Schwann cells in culture. The increased expression of CD59 in EAN is likely to be important in the protection of Schwann cells from MAC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Neuritis  ISOCd59b (Rattus norvegicus)1600494; 1600494protein:increased expression:Schwann cell (rat)RGD 
Experimental Autoimmune Neuritis  IEP 1600494protein:increased expression:Schwann cell (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd59b  (CD59b molecule)

Genes (Mus musculus)
Cd59b  (CD59b antigen)

Genes (Homo sapiens)
CD59  (CD59 molecule (CD59 blood group))

Objects referenced in this article
Gene Cd59a CD59a antigen Mus musculus

Additional Information