RGD Reference Report - Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model. - Rat Genome Database

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Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model.

Authors: Roshani, L  Wedekind, D  Szpirer, J  Taib, Z  Szpirer, C  Beckmann, B  Riviere, M  Hedrich, HJ  Klinga-Levan, K 
Citation: Roshani L, etal., Int J Cancer. 2001 Dec 15;94(6):795-9.
RGD ID: 1599856
Pubmed: PMID:11745480   (View Abstract at PubMed)

There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we have performed a genetic analysis of susceptibility to endometrial cancer in this strain. F(2) populations were generated by crossing BDII females with males from 2 different strains with a low incidence of EAC, and the occurrence of endometrial cancer was studied. Three chromosome regions associated to EAC susceptibility were identified, and the susceptibility genes in these regions were designated Ecs1, Ecs2 and Ecs3. Our results indicate that the genes affecting susceptibility to EAC are different in the 2 crosses, suggesting that the genes behind the susceptibility in BDII animals may interact with different genes in different genetic backgrounds.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Edcs1RatEndometrial Neoplasms susceptibilityIDA  RGD 
Edcs2RatEndometrial Neoplasms susceptibilityIDA  RGD 
Edcs3RatEndometrial Neoplasms susceptibilityIDA  RGD 
Edcs4RatEndometrial Neoplasms susceptibilityIDA  RGD 
Edcs5RatEndometrial Neoplasms susceptibilityIDA  RGD 
Edcs1RatEndometrioid Carcinomas susceptibilityIDA  RGD 
Edcs2RatEndometrioid Carcinomas susceptibilityIDA  RGD 
Edcs3RatEndometrioid Carcinomas susceptibilityIDA  RGD 
Edcs4RatEndometrioid Carcinomas susceptibilityIDA  RGD 
Edcs5RatEndometrioid Carcinomas susceptibilityIDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Edcs1Ratincreased endometrial carcinoma incidence susceptibilityIDA  RGD 
Edcs2Ratincreased endometrial carcinoma incidence susceptibilityIDA  RGD 
Edcs3Ratincreased endometrial carcinoma incidence susceptibilityIDA  RGD 
Edcs4Ratincreased endometrial carcinoma incidence susceptibilityIDA  RGD 
Edcs5Ratincreased endometrial carcinoma incidence susceptibilityIDA  RGD 
Objects Annotated

Edcs1  (Endometrial carcinoma susceptibility QTL1)
Edcs2  (Endometrial carcinoma susceptibility QTL2)
Edcs3  (Endometrial carcinoma susceptibility QTL3)
Edcs4  (Endometrial carcinoma susceptibility QTL 4)
Edcs5  (Endometrial carcinoma susceptibility QTL 5)

BDII/Ztm  (NA)
BN/Han  (NA)
SPRD/Ztm  (NA)

Additional Information