RGD Reference Report - p19 detected in the rat retina and pineal gland is a guanylyl cyclase-activating protein (GCAP). - Rat Genome Database

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p19 detected in the rat retina and pineal gland is a guanylyl cyclase-activating protein (GCAP).

Authors: Dejda, A  Matczak, I  Gorczyca, WA 
Citation: Dejda A, etal., Acta Biochim Pol. 2002;49(4):899-905.
RGD ID: 1599357
Pubmed: PMID:12545196   (View Abstract at PubMed)
DOI: DOI:024904899   (Journal Full-text)

The Ca(2+)-dependent activation of retina-specific guanylyl cyclase (retGC) is mediated by guanylyl cyclase-activating proteins (GCAPs). Here we report for the first time detection of a 19 kDa protein (p19) with GCAP properties in extracts of rat retina and pineal gland. Both extracts stimulate synthesis of cGMP in rod outer segment (ROS) membranes at low (30 nM) but not at high (1 microM) concentrations of Ca(2+). At low Ca(2+), immunoaffinity purified p19 activates guanylyl cyclase(s) in bovine ROS and rat retinal membranes. Moreover, p19 is recognized by antibodies against bovine GCAP1 and, similarly to other GCAPs, exhibits a Ca(2+)-dependent electrophoretic mobility shift.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Guca1aRatpositive regulation of cGMP-mediated signaling  IDA  RGD 
Guca1aRatpositive regulation of guanylate cyclase activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Guca1a  (guanylate cyclase activator 1A)


Additional Information