RGD Reference Report - Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. - Rat Genome Database

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Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.

Authors: Quan, X  Laes, JF  Stieber, D  Riviere, M  Russo, J  Wedekind, D  Coppieters, W  Farnir, F  Georges, M  Szpirer, J  Szpirer, C 
Citation: Quan X, etal., Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.
RGD ID: 1599317
Pubmed: PMID:16596452   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-005-0125-9   (Journal Full-text)

The rat is considered an excellent model for studying human breast cancer. Therefore, understanding the genetic basis of susceptibility to mammary cancer in this species is of great interest. Previous studies based on crosses involving the susceptible strain WF (crossed with the resistant strains COP or WKY) and focusing on tumor multiplicity as the susceptibility phenotype led to the identification of several loci that control chemically induced mammary cancer. The present study was aimed to determine whether other loci can be identified by analyzing crosses derived from another susceptible strain on the one hand, and by including phenotypes other than tumor multiplicity on the other hand. A backcross was generated between the susceptible SPRD-Cu3 strain and the resistant WKY strain. Female progeny were genotyped with microsatellite markers covering all rat autosomes, treated with a single dose of DMBA, and phenotyped with respect to tumor latency, tumor multiplicity, and tumor aggressiveness. Seven loci controlling mammary tumor development were detected. Different loci control tumor multiplicity, latency, and aggressiveness. While some of these loci colocalize with loci identified in crosses involving the susceptible strain WF, new loci have been uncovered, indicating that the use of distinct susceptible and resistant strain pairs will help in establishing a comprehensive inventory of mammary cancer susceptibility loci.

Disease Annotations    

Phenotype Annotations    
Objects Annotated

Mcs16  (Mammary carcinoma susceptibility QTL 16)
Mcs17  (Mammary carcinoma susceptibility QTL 17)
Mcs18  (Mammary carcinoma susceptibility QTL 18)
Mcs19  (Mammary carcinoma susceptibility QTL 19)
Mcs20  (Mammary carcinoma susceptibility QTL 20)
Mcs21  (Mammary carcinoma susceptibility QTL 21)
Mcs22  (Mammary carcinoma susceptibility QTL 22)

SPRD/Ztm  (NA)
WKY/Ztm  (NA)

Additional Information