RGD Reference Report - Developmental and tissue-specific modulation of rat galactose-1-phosphate uridyltransferase steady state messenger RNA and specific activity levels. - Rat Genome Database

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Developmental and tissue-specific modulation of rat galactose-1-phosphate uridyltransferase steady state messenger RNA and specific activity levels.

Authors: Heidenreich, RA  Mallee, J  Rogers, S  Segal, S 
Citation: Heidenreich RA, etal., Pediatr Res. 1993 Oct;34(4):416-9.
RGD ID: 1598677
Pubmed: PMID:8255669   (View Abstract at PubMed)
DOI: DOI:10.1203/00006450-199310000-00006   (Journal Full-text)

To assess the role of genetic regulation as a modulating factor in the variability of rat tissue galactose-1-phosphate uridyltransferase (GALT) sp act, we have determined steady state GALT mRNA and sp act in rat liver during postnatal development. Steady state GALT mRNA levels increase from birth to d 5 and subsequently decrease toward adult levels. GALT sp act mirrors the mRNA pattern. A survey of steady state mRNA and GALT sp act of several adult rat tissues revealed marked tissue differences with a good correlation of the two parameters. Liver had the highest GALT mRNA and sp act; kidney, ovary, and heart had similar but lower mRNA and sp act; skeletal muscle and testes had the least GALT mRNA and enzyme sp act. These findings suggest that genetic regulation is important in the variable expression of GALT tissue sp act.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GaltRatgalactose metabolic process  IDA  RGD 
GaltRatUDP-alpha-D-glucose catabolic process  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GaltRatD-glucose binding  ICGO:0008108 RGD 
GaltRatgalactose binding  ICGO:0008108 RGD 
GaltRatUDP-glucose:hexose-1-phosphate uridylyltransferase activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Galt  (galactose-1-phosphate uridylyltransferase)


Additional Information