RGD Reference Report - Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. - Rat Genome Database

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Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin.

Authors: Seiler, N  Grauffel, C  Elands, J  Van den Buuse, M  Knodgen, B  Sarhan, S  Moran, P  Gobaille, S 
Citation: Seiler N, etal., Pharmacol Biochem Behav. 1995 Feb;50(2):181-9.
RGD ID: 1598524
Pubmed: PMID:7740056   (View Abstract at PubMed)

Acute and chronic administration of vigabatrin, a selective inactivator of GABA-T, suppresses haloperidol-induced dyskinesias at low doses without preventing the enhancement of striatal dopamine D2 receptor density or the development of vacuous chewing movements. The long-term administration of vigabatrin does not attenuate its effect. The observations presented in this work support the GABA hypothesis of haloperidol-induced vacuous chewing behavior in rats, and suggest that vigabatrin is an appropriate means to enhance nigral GABAergic activity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABATHumanDrug-Induced Dyskinesia  ISOAbat (Rattus norvegicus) RGD 
AbatRatDrug-Induced Dyskinesia  IMP  RGD 
AbatMouseDrug-Induced Dyskinesia  ISOAbat (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abat  (4-aminobutyrate aminotransferase)

Genes (Mus musculus)
Abat  (4-aminobutyrate aminotransferase)

Genes (Homo sapiens)
ABAT  (4-aminobutyrate aminotransferase)


Additional Information