RGD Reference Report - MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. - Rat Genome Database

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MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations.

Authors: Chen, Y  Fan, Y  Poon, KY  Achrol, AS  Lawton, MT  Zhu, Y  McCulloch, CE  Hashimoto, T  Lee, C  Barbaro, NM  Bollen, AW  Yang, GY  Young, WL 
Citation: Chen Y, etal., Front Biosci. 2006 Sep 1;11:3121-8.
RGD ID: 1582655
Pubmed: PMID:16720380   (View Abstract at PubMed)

Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n = 5), BAVM tissue (n = 139) had a higher expression (by ELISA) of myeloperoxidase (MPO) (193 +/- 189 vs. 6 +/- 3, ng/mg, P < .001), MMP-9 (28 +/- 32 vs. 0.7 +/- 0.6, ng/mg, P < .001), and IL-6 (102 +/- 218 vs. 0.1 +/- 0.1, pg/mg, P < .001), but not eNOS (114 +/- 87 vs. 65 +/- 9, pg/mg, P = .09). MMP-9 expression in BAVM highly correlated with myeloperoxidase (R2 = .76, P < .001), as well as with IL-6 (R2 = .32, P < .001). In contrast, MMP-9 in BAVM poorly correlated with the endothelial marker, eNOS (R2 = .03, P = .05), and CD31 (R2 = .004, P = .57). Compared to non-embolized patients (n = 46), patients with pre-operative embolization (n = 93) had higher levels of myeloperoxidase (236 +/- 205 vs. 106 +/- 108, ng/mg, P < .001) and MMP-9 (33 +/- 35 vs. 16 +/- 20, ng/mg, P < .001), however the correlation between MMP-9 and myeloperoxidase was equally strong for both groups (R2 = .69, n = 93, P < .001, for both). MMP-9 expression correlated with the lipocalin-MMP-9 complex, suggesting neutrophils as the MMP-9 source. MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MMP9Humanarteriovenous malformation  IEP  RGD 
Mmp9Ratarteriovenous malformation  ISOMMP9 (Homo sapiens) RGD 
Mmp9Mousearteriovenous malformation  ISOMMP9 (Homo sapiens) RGD 
MMP9HumanEmbolism  IEP  RGD 
Mmp9RatEmbolism  ISOMMP9 (Homo sapiens) RGD 
Mmp9MouseEmbolism  ISOMMP9 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)


Additional Information