RGD Reference Report - Quest for arthritis-causative genetic factors in the rat. - Rat Genome Database

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Quest for arthritis-causative genetic factors in the rat.

Authors: Joe, B 
Citation: Joe B Physiol Genomics. 2006 Oct 3;27(1):1-11. Epub 2006 Jun 27.
RGD ID: 1582387
Pubmed: PMID:16804090   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00034.2005   (Journal Full-text)

Experimental rat models of arthritis are extensively studied with a view to understand the genetic underpinnings of rheumatoid arthritis (RA). Genome scans using these models have led to the detection of arthritis regulatory quantitative trait loci (QTLs) on all but three chromosomes of the rat. Whereas some of the QTLs are model specific, others overlap between models. Some arthritis susceptibility and/or severity QTLs identified by genetic linkage analyses are corroborated by substitution mapping using congenic strains, whereas others are not. In these cases, testing alternate arthritis models proved to be useful to identify QTL effects. Nevertheless, development and testing of congenic substrains containing progressively shorter introgressed regions have not only fine mapped the location of the arthritis QTLs but also resulted in the identification of multiple QTLs within several originally identified individual QTL. Most of these studies progressed rapidly since 2001, when the rat genome sequence was published. Proof of principle for substitution mapping as a successful method for QTL gene discovery is provided by the positional cloning of Ncf1 as one of the arthritis QTLs in rats. This finding is encouraging for similar sustained dissection of all the other arthritis QTLs mapped in the rat. Identification of rat arthritis QTLs is expected to pave the way for discovery of yet-unidentified arthritis-causative genetic elements and/or pathways for RA in humans and potential development of targeted therapeutics. This review catalogs some of the recent advances made in QTL discovery projects of experimentally induced rat models of arthritis.



Objects referenced in this article
QTL Aia1 Adjuvant induced arthritis QTL 1 Rattus norvegicus
QTL Aia2 Adjuvant induced arthritis QTL 2 Rattus norvegicus
QTL Aia3 Adjuvant induced arthritis QTL 3 Rattus norvegicus
QTL Aia4 Adjuvant induced arthritis QTL 4 Rattus norvegicus
QTL Apr1 Acute phase response QTL 1 Rattus norvegicus
QTL Apr2 Acute phase response QTL 2 Rattus norvegicus
QTL Cia1 Collagen induced arthritis QTL 1 Rattus norvegicus
QTL Cia10 Collagen induced arthritis QTL 10 Rattus norvegicus
QTL Cia11 Collagen induced arthritis QTL 11 Rattus norvegicus
QTL Cia12 Collagen induced arthritis QTL 12 Rattus norvegicus
QTL Cia13 Collagen induced arthritis QTL 13 Rattus norvegicus
QTL Cia14 Collagen induced arthritis QTL 14 Rattus norvegicus
QTL Cia15 Collagen induced arthritis QTL 15 Rattus norvegicus
QTL Cia16 Collagen induced arthritis QTL 16 Rattus norvegicus
QTL Cia17 Collagen induced arthritis QTL 17 Rattus norvegicus
QTL Cia18 Collagen induced arthritis QTL 18 Rattus norvegicus
QTL Cia19 Collagen induced arthritis QTL 19 Rattus norvegicus
QTL Cia2 Collagen induced arthritis QTL 2 Rattus norvegicus
QTL Cia24 Collagen induced arthritis QTL 24 Rattus norvegicus
QTL Cia25 Collagen induced arthritis QTL 25 Rattus norvegicus
QTL Cia26 Collagen induced arthritis QTL 26 Rattus norvegicus
QTL Cia3 Collagen induced arthritis QTL 3 Rattus norvegicus
QTL Cia4 Collagen induced arthritis QTL 4 Rattus norvegicus
QTL Cia5 Collagen induced arthritis QTL 5 Rattus norvegicus
QTL Cia6 Collagen induced arthritis QTL 6 Rattus norvegicus
QTL Cia7 Collagen induced arthritis QTL 7 Rattus norvegicus
QTL Ciaa1 CIA Autoantibody QTL 1 Rattus norvegicus
QTL Ciaa2 CIA Autoantibody QTL 2 Rattus norvegicus
QTL Ciaa3 CIA Autoantibody QTL 3 Rattus norvegicus
QTL Ciaa4 CIA Autoantibody QTL 4 Rattus norvegicus
QTL Ciaa5 CIA Autoantibody QTL 5 Rattus norvegicus
QTL Oia2 Oil induced arthritis QTL 2 Rattus norvegicus
QTL Oia3 Oil induced arthritis QTL 3 Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus
QTL Pia11 Pristane induced arthritis QTL 11 Rattus norvegicus
QTL Pia12 Pristane induced arthritis QTL 12 Rattus norvegicus
QTL Pia13 Pristane induced arthritis QTL 13 Rattus norvegicus
QTL Pia14 Pristane induced arthritis QTL 14 Rattus norvegicus
QTL Pia15 Pristane induced arthritis QTL 15 Rattus norvegicus
QTL Pia16 Pristane induced arthritis QTL 16 Rattus norvegicus
QTL Pia17 Pristane induced arthritis QTL 17 Rattus norvegicus
QTL Pia18 Pristane induced arthritis QTL 18 Rattus norvegicus
QTL Pia19 Pristane induced arthritis QTL 19 Rattus norvegicus
QTL Pia2 Pristane induced arthritis QTL 2 Rattus norvegicus
QTL Pia21 Pristane induced arthritis QTL 21 Rattus norvegicus
QTL Pia22 Pristane induced arthritis QTL 22 Rattus norvegicus
QTL Pia23 Pristane induced arthritis QTL 23 Rattus norvegicus
QTL Pia3 Pristane induced arthritis QTL 3 Rattus norvegicus
QTL Pia4 Pristane induced arthritis QTL 4 Rattus norvegicus
QTL Pia5 Pristane induced arthritis QTL 5 Rattus norvegicus
QTL Pia6 Pristane induced arthritis QTL 6 Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus
QTL Pia8 Pristane induced arthritis QTL 8 Rattus norvegicus

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