RGD Reference Report - Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. - Rat Genome Database

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

Authors: Guy, CT  Webster, MA  Schaller, M  Parsons, TJ  Cardiff, RD  Muller, WJ 
Citation: Guy CT, etal., Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10578-82.
RGD ID: 1582128
Pubmed: PMID:1359541   (View Abstract at PubMed)
PMCID: PMC50384   (View Article at PubMed Central)

Overexpression and amplification of the neu (c-erbB2, ERBB2) protooncogene have been implicated in the development of aggressive human breast cancer. To directly assess the effect of mammary gland-specific expression of the neu protooncogene, transgenic mice carrying unactivated neu under the transcriptional control of the mouse mammary tumor virus promoter/enhancer were established. By contrast to the rapid tumor progression observed in several transgenic strains carrying the activated neu transgene, expression of unactivated neu in the mammary epithelium resulted in the development of focal mammary tumors after long latency. The majority of the mammary tumors analyzed expressed elevated levels of neu-encoded mRNA and protein. Overexpression of neu in the mammary tumors was also associated with elevated neu intrinsic tyrosine kinase activity and the de novo tyrosine phosphorylation of several cellular proteins. Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Erbb2Ratprotein autophosphorylation  IDA  RGD 

Molecular Function

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Erbb2Ratprotein tyrosine kinase activity  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Erbb2Ratincreased metastatic potential  IDA  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Additional Information