RGD Reference Report - Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. - Rat Genome Database

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Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum.

Authors: Ueda, H  Baba, T  Terada, N  Kato, Y  Fujii, Y  Takayama, I  Mei, X  Ohno, S 
Citation: Ueda H, etal., Neurosci Lett. 2000 Apr 7;283(2):121-4.
RGD ID: 1581692
Pubmed: PMID:10739890   (View Abstract at PubMed)

Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrobrevin in the adult rat cerebellum immunohistochemically. Confocal microscopy showed that dystrobrevin was expressed around blood vessels and under the pia mater as dystrophin, utrophin and beta-dystroglycan were. Immunoelectron microscopy demonstrated that dystrobrevin was localized not only in the astrocytic endfeet around blood vessels and under the pia mater, but also in endothelial cells. Considering the fact that dystrobrevin possesses multiple phosphotyrosine kinase residues, these data suggest that dystrobrevin plays a role in blood-brain barrier functions as a component of the dystrophin complex.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DtnaRatcell projection  IDA astrocyte endfeetRGD 

Objects Annotated

Genes (Rattus norvegicus)
Dtna  (dystrobrevin, alpha)


Additional Information