RGD Reference Report - Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. - Rat Genome Database

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Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.

Authors: Pandey, J  Wendell, DL 
Citation: Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
RGD ID: 1581610
Pubmed: PMID:16416090   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-005-2450-4   (Journal Full-text)

The quantitative trait locus (QTL) Edpm3 is one of a group of additively acting QTL \responsible for the difference in estrogen-induced pituitary tumor growth between the tumor-susceptible F344 and tumor-resistant BN rat strains. The F344.BN-Edpm3(BN) rat strain was produced by moving the segment of rat Chr 3 between D3Mgh7 and D3Mgh13, which contains the Edpm3 QTL, from the BN strain into the F344 genetic background. In a previous study, we used this congenic line to find that the BN allele of the Edpm3 QTL reduces tissue mass and S-phase fraction in the estrogen-induced rat pituitary tumor. We now report on the use of this congenic line to investigate the linkage of Edpm3 to tumor angiogenesis. Contrary to expectation, the F344.BN-Edpm3(BN) strain has significantly greater angiogenic activity than does F344 in both treated and untreated rats. Microvessel count (MVC), perivascular space, and number of nonattached pericytes/pericapillary fibroblasts are all elevated in the pituitary by chronic estrogen treatment and their values are significantly greater in F344.BN-Edpm3(BN) than F344. Thus, although there is greater angiogenic activity in the pituitary of estrogen-treated F344.BN-Edpm3(BN) rats, there is a deficiency in capillary maturation compared with F344.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatpituitary adenoma inducedIAGPdiethylstilbestrol RGD 
F344/NHsdRatpituitary adenoma inducedIAGPdiethylstilbestrol RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nrp1Ratprotein binding  IPIFgf1 (Rattus norvegicus) RGD 
Nrp1Ratprotein binding  IPIFgf2 (Rattus norvegicus) RGD 
Nrp1Ratprotein binding  IPIHgf (Rattus norvegicus) RGD 
Nrp1Ratprotein binding  IPIFgf7 (Rattus norvegicus) RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased capillary density  IAGP compared to F344/NHsdRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased capillary density inducedIAGPdiethylstilbestrolcompared to F344.BN-D3Mgh13-D3Mgh7/Dlw and diethylstilbestrol treated F344/NHsdRGD 
F344/NHsdRatincreased capillary density inducedIAGPdiethylstilbestrolcompared to F344/NHsdRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased lactotroph cell number inducedIAGPdiethylstilbestrolcompared to F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
F344/NHsdRatincreased lactotroph cell number inducedIAGPdiethylstilbestrolcompared to F344/NHsd and diethylstilbestrol treated F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
F344/NHsdRatincreased lactotroph cell number  IAGP compared to F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased tumor nonattached pericyte number  IAGP compared to F344/NHsdRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased tumor nonattached pericyte number inducesIAGPdiethylstilbestrolcompared to diethylstilbestrol treated F344/NHsdRGD 
F344/NHsdRatincreased tumor nonattached pericyte number inducesIAGPdiethylstilbestrolcompared to F344/NHsdRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased tumor perivascular space size  IAGP compared to F344/NHsdRGD 
F344.BN-(D3Mgh13-D3Mgh7)/DlwRatincreased tumor perivascular space size inducesIAGPdiethylstilbestrolcompared to diethylstilbestrol treated F344/NHsdRGD 

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Objects Annotated

Genes (Rattus norvegicus)
Nrp1  (neuropilin 1)

Strains
F344.BN-(D3Mgh13-D3Mgh7)/Dlw  (NA)
F344/NHsd  (F344/NHsd)

Objects referenced in this article
QTL Edpm3 Estrogen-dependent pituitary mass QTL 3 Rattus norvegicus
Gene Fgf1 fibroblast growth factor 1 Rattus norvegicus
Gene Fgf2 fibroblast growth factor 2 Rattus norvegicus
Gene Fgf7 fibroblast growth factor 7 Rattus norvegicus
Gene Hgf hepatocyte growth factor Rattus norvegicus

Additional Information