RGD Reference Report - Von Willebrand factor antigen levels in Behcet disease. - Rat Genome Database

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Von Willebrand factor antigen levels in Behcet disease.

Authors: Beyan, E  Sadikoglu, B  Ertugrul, E  Beyan, C 
Citation: Beyan E, etal., Am J Hematol. 2005 May;79(1):70-2.
RGD ID: 1580642
Pubmed: PMID:15849757   (View Abstract at PubMed)
DOI: DOI:10.1002/ajh.20317   (Journal Full-text)

High von Willebrand factor antigen (vWF:Ag) levels can be found due to vascular endothelial injury in Behcet disease. The aim of this study is to evaluate whether there is any relationship between vWF:Ag levels and vascular or other organ involvements and acute-phase reactants in Behcet disease. Fifteen controls and 17 Behcet's patients were included; 10 had oral ulcers, 5 had genital ulcers, 3 had skin lesions, 6 had ocular involvement, 5 had arthritis, and 6 had vascular involvement. VWF:Ag levels were higher in Behcet's patients than controls. VWF:Ag levels in Behcet's patients with oral ulcers, genital ulcers, and ocular and vascular involvement were statistically higher than in the control group. Differences between vWF:Ag levels in Behcet's patients with and without organ involvement were not statistically significant. A linear correlation between serum ferritin levels and vWF:Ag levels was observed. These results demonstrate that elevated levels of plasma vWF:Ag are related to Behcet disease exacerbation rather than vascular involvement.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease  IDA 1580642 RGD 
Behcet's disease  ISOVWF (Homo sapiens)1580642; 1580642 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Vwf  (von Willebrand factor)

Genes (Mus musculus)
Vwf  (Von Willebrand factor)

Genes (Homo sapiens)
VWF  (von Willebrand factor)

Additional Information