RGD Reference Report - Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. - Rat Genome Database

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Science review: Vasopressin and the cardiovascular system part 1--receptor physiology.

Authors: Holmes, CL  Landry, DW  Granton, JT 
Citation: Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
RGD ID: 1579891
Pubmed: PMID:14624682   (View Abstract at PubMed)
PMCID: PMC374366   (View Article at PubMed Central)
DOI: DOI:10.1186/cc2337   (Journal Full-text)

Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents, vasopressin also has vasodilatory properties. The goal of the present review is to explore the vascular actions of vasopressin. In part 1 of the review we discuss structure, signaling pathways, and tissue distributions of the classic vasopressin receptors, namely V1 vascular, V2 renal, V3 pituitary and oxytocin receptors, and the P2 class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions of vasopressin on the vascular system. In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart, and we summarize clinical studies of vasopressin in shock states.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
OxtRatlactation  TAS  RGD 
OxtRatparturition  TAS  RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AVPR1AHumanG protein mediated signaling pathway via Galphaq family  TAS  RGD 
AVPR1BHumanG protein mediated signaling pathway via Galphaq family  TAS  RGD 
Avpr1aRatG protein mediated signaling pathway via Galphaq family  ISOAVPR1A (Homo sapiens) RGD 
Avpr1aMouseG protein mediated signaling pathway via Galphaq family  ISOAVPR1A (Homo sapiens) RGD 
Avpr1bMouseG protein mediated signaling pathway via Galphaq family  ISOAVPR1B (Homo sapiens) RGD 
Avpr1bRatG protein mediated signaling pathway via Galphaq family  ISOAVPR1B (Homo sapiens) RGD 
GNA11HumanG protein mediated signaling pathway via Galphaq family  TAS  RGD 
GNAQHumanG protein mediated signaling pathway via Galphaq family  TAS  RGD 
Gna11RatG protein mediated signaling pathway via Galphaq family  ISOGNA11 (Homo sapiens) RGD 
Gna11MouseG protein mediated signaling pathway via Galphaq family  ISOGNA11 (Homo sapiens) RGD 
GnaqRatG protein mediated signaling pathway via Galphaq family  ISOGNAQ (Homo sapiens) RGD 
GnaqMouseG protein mediated signaling pathway via Galphaq family  ISOGNAQ (Homo sapiens) RGD 
OXTRHumanG protein mediated signaling pathway via Galphaq family  TAS  RGD 
OxtrRatG protein mediated signaling pathway via Galphaq family  ISOOXTR (Homo sapiens) RGD 
OxtrMouseG protein mediated signaling pathway via Galphaq family  ISOOXTR (Homo sapiens) RGD 
AVPR2HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
Avpr2RatG protein mediated signaling pathway via Galphas family  ISOAVPR2 (Homo sapiens) RGD 
Avpr2MouseG protein mediated signaling pathway via Galphas family  ISOAVPR2 (Homo sapiens)mRGD 
GNASHumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
GnasRatG protein mediated signaling pathway via Galphas family  ISOGNAS (Homo sapiens) RGD 
GnasMouseG protein mediated signaling pathway via Galphas family  ISOGNAS (Homo sapiens) RGD 
GNA11Humanoxytocin signaling pathway  TAS  RGD 
GNAQHumanoxytocin signaling pathway  TAS  RGD 
Gna11Mouseoxytocin signaling pathway  ISOGNA11 (Homo sapiens) RGD 
Gna11Ratoxytocin signaling pathway  ISOGNA11 (Homo sapiens) RGD 
GnaqMouseoxytocin signaling pathway  ISOGNAQ (Homo sapiens) RGD 
GnaqRatoxytocin signaling pathway  ISOGNAQ (Homo sapiens) RGD 
OXTHumanoxytocin signaling pathway  TAS  RGD 
OXTRHumanoxytocin signaling pathway  TAS  RGD 
OxtMouseoxytocin signaling pathway  ISOOXT (Homo sapiens) RGD 
OxtRatoxytocin signaling pathway  ISOOXT (Homo sapiens) RGD 
OxtrRatoxytocin signaling pathway  ISOOXTR (Homo sapiens) RGD 
OxtrMouseoxytocin signaling pathway  ISOOXTR (Homo sapiens) RGD 
AVPHumanvasopressin signaling pathway   TAS  RGD 
AVPR1AHumanvasopressin signaling pathway   TAS  RGD 
AVPR1BHumanvasopressin signaling pathway   TAS  RGD 
AVPR2Humanvasopressin signaling pathway   TAS  RGD 
AvpRatvasopressin signaling pathway   ISOAVP (Homo sapiens) RGD 
AvpMousevasopressin signaling pathway   ISOAVP (Homo sapiens) RGD 
Avpr1aMousevasopressin signaling pathway   ISOAVPR1A (Homo sapiens) RGD 
Avpr1aRatvasopressin signaling pathway   ISOAVPR1A (Homo sapiens) RGD 
Avpr1bRatvasopressin signaling pathway   ISOAVPR1B (Homo sapiens) RGD 
Avpr1bMousevasopressin signaling pathway   ISOAVPR1B (Homo sapiens) RGD 
Avpr2Mousevasopressin signaling pathway   ISOAVPR2 (Homo sapiens) RGD 
Avpr2Ratvasopressin signaling pathway   ISOAVPR2 (Homo sapiens) RGD 
GNA11Humanvasopressin signaling pathway   TAS  RGD 
GNAQHumanvasopressin signaling pathway   TAS  RGD 
GNASHumanvasopressin signaling pathway   TAS  RGD 
Gna11Mousevasopressin signaling pathway   ISOGNA11 (Homo sapiens) RGD 
Gna11Ratvasopressin signaling pathway   ISOGNA11 (Homo sapiens) RGD 
GnaqMousevasopressin signaling pathway   ISOGNAQ (Homo sapiens) RGD 
GnaqRatvasopressin signaling pathway   ISOGNAQ (Homo sapiens) RGD 
GnasMousevasopressin signaling pathway   ISOGNAS (Homo sapiens) RGD 
GnasRatvasopressin signaling pathway   ISOGNAS (Homo sapiens) RGD 
AVPHumanvasopressin signaling pathway via receptor type 1  TAS  RGD 
AVPR1AHumanvasopressin signaling pathway via receptor type 1  TAS  RGD 
AVPR1BHumanvasopressin signaling pathway via receptor type 1  TAS  RGD 
AvpMousevasopressin signaling pathway via receptor type 1  ISOAVP (Homo sapiens) RGD 
AvpRatvasopressin signaling pathway via receptor type 1  ISOAVP (Homo sapiens) RGD 
Avpr1aMousevasopressin signaling pathway via receptor type 1  ISOAVPR1A (Homo sapiens) RGD 
Avpr1aRatvasopressin signaling pathway via receptor type 1  ISOAVPR1A (Homo sapiens) RGD 
Avpr1bRatvasopressin signaling pathway via receptor type 1  ISOAVPR1B (Homo sapiens) RGD 
Avpr1bMousevasopressin signaling pathway via receptor type 1  ISOAVPR1B (Homo sapiens) RGD 
GNA11Humanvasopressin signaling pathway via receptor type 1  TAS  RGD 
GNAQHumanvasopressin signaling pathway via receptor type 1  TAS  RGD 
Gna11Mousevasopressin signaling pathway via receptor type 1  ISOGNA11 (Homo sapiens) RGD 
Gna11Ratvasopressin signaling pathway via receptor type 1  ISOGNA11 (Homo sapiens) RGD 
GnaqMousevasopressin signaling pathway via receptor type 1  ISOGNAQ (Homo sapiens) RGD 
GnaqRatvasopressin signaling pathway via receptor type 1  ISOGNAQ (Homo sapiens) RGD 
AVPHumanvasopressin signaling pathway via receptor type 2   TAS  RGD 
AVPR2Humanvasopressin signaling pathway via receptor type 2   TAS  RGD 
AvpMousevasopressin signaling pathway via receptor type 2   ISOAVP (Homo sapiens) RGD 
AvpRatvasopressin signaling pathway via receptor type 2   ISOAVP (Homo sapiens) RGD 
Avpr2Mousevasopressin signaling pathway via receptor type 2   ISOAVPR2 (Homo sapiens) RGD 
Avpr2Ratvasopressin signaling pathway via receptor type 2   ISOAVPR2 (Homo sapiens) RGD 
GNASHumanvasopressin signaling pathway via receptor type 2   TAS  RGD 
GnasMousevasopressin signaling pathway via receptor type 2   ISOGNAS (Homo sapiens) RGD 
GnasRatvasopressin signaling pathway via receptor type 2   ISOGNAS (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)
Avpr1a  (arginine vasopressin receptor 1A)
Avpr1b  (arginine vasopressin receptor 1B)
Avpr2  (arginine vasopressin receptor 2)
Gna11  (G protein subunit alpha 11)
Gnaq  (G protein subunit alpha q)
Gnas  (GNAS complex locus)
Oxt  (oxytocin/neurophysin I prepropeptide)
Oxtr  (oxytocin receptor)

Genes (Mus musculus)
Avp  (arginine vasopressin)
Avpr1a  (arginine vasopressin receptor 1A)
Avpr1b  (arginine vasopressin receptor 1B)
Avpr2  (arginine vasopressin receptor 2)
Gna11  (guanine nucleotide binding protein, alpha 11)
Gnaq  (guanine nucleotide binding protein, alpha q polypeptide)
Gnas  (GNAS complex locus)
Oxt  (oxytocin)
Oxtr  (oxytocin receptor)

Genes (Homo sapiens)
AVP  (arginine vasopressin)
AVPR1A  (arginine vasopressin receptor 1A)
AVPR1B  (arginine vasopressin receptor 1B)
AVPR2  (arginine vasopressin receptor 2)
GNA11  (G protein subunit alpha 11)
GNAQ  (G protein subunit alpha q)
GNAS  (GNAS complex locus)
OXT  (oxytocin/neurophysin I prepropeptide)
OXTR  (oxytocin receptor)


Additional Information