RGD Reference Report - Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat. - Rat Genome Database

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Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.

Authors: Gould, KA  Strecker, TE  Hansen, KK  Bynote, KK  Peterson, KA  Shull, JD 
Citation: Gould KA, etal., Mamm Genome. 2006 May;17(5):451-64.
RGD ID: 1579780
Pubmed: (View Article at PubMed) PMID:16688534
DOI: Full-text: DOI:10.1007/s00335-005-0183-z

Chronic estrogen administration can lead to thymic atrophy in rodents. In this article we report that the Brown Norway (BN) rat is sensitive to thymic atrophy induced by the estrogen diethylstilbestrol (DES). By contrast, DES does not induce significant thymic atrophy in the August x Copenhagen-Irish (ACI) strain. The sensitivity of the BN rat to DES-induced thymic atrophy appears to segregate as an incompletely dominant trait in crosses between the BN and ACI strains. In a (BN x ACI)F(2) population, we find strong evidence for three major genetic determinants of sensitivity to DES-induced thymic atrophy on rat Chromosome (RNO) 10 and RNO2. Genotypes at these loci, termed Esta1, 2, and 3, do not have a significant impact on the ability of DES to induce pituitary tumorigenesis or inhibit growth of these F(2) rats. These data indicate that the genetic factors that control DES-induced thymic atrophy are distinct from those that control the effects of DES on pituitary mass and body mass. The Esta intervals on RNO10 and RNO2 overlap with loci that control sensitivity to radiation-induced thymocyte apoptosis, as well as susceptibility to a variety of allergic and autoimmune pathologies, including allergic encephalitis, arthritis, and glomerulonephritis in rodents. These observations suggest that common genetic determinants may control sensitivity to estrogen-induced thymic atrophy, maintenance of thymocyte homeostasis, and immune function.




Related Phenotype Data for Reference

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer data
BN/SsNHsd ACI/SegHsd

Objects Annotated

QTLs
Esta1  (Estrogen-induced thymic atrophy QTL 1)
Esta2  (Estrogen-induced thymic atrophy QTL 2)
Esta3  (Estrogen-induced thymic atrophy QTL 3)

Objects referenced in this article
Strain ACI/SegHsd null Rattus norvegicus
Strain BN/SsNHsd null Rattus norvegicus

Additional Information