RGD Reference Report - Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. - Rat Genome Database

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Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats.

Authors: Yamazato, M  Ohya, Y  Nakamoto, M  Sakima, A  Tagawa, T  Harada, Y  Nabika, T  Takishita, S 
Citation: Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
RGD ID: 1578503
Pubmed: PMID:16239369   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpregu.00610.2005   (Journal Full-text)

A chromosome 1 blood pressure quantitative trait locus (QTL) was introgressed from the stroke-prone spontaneously hypertensive rats (SHRSP) to Wistar-Kyoto (WKY) rats. This congenic strain (WKYpch1.0) showed an exaggerated pressor response to both restraint and cold stress. In this study, we evaluated cardiovascular and sympathetic response to an air-jet stress and also examined the role of the brain renin-angiotensin system (RAS) in the stress response of WKYpch1.0. We measured mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) responses to air-jet stress in WKYpch1.0, WKY, and SHRSP. We also examined effects of intracerebroventricular administration of candesartan, an ANG II type 1 receptor blocker, on MAP and HR responses to air-jet stress. Baseline MAP in the WKYpch1.0 and WKY rats were comparable, while it was lower than that in SHRSP rats. Baseline HR did not differ among the strains. In WKYpch1.0, air-jet stress caused greater increase in MAP and RSNA than in WKY. The increase in RSNA was as large as that in SHRSP, whereas the increase in MAP was smaller than in SHRSP. Intracerebroventricular injection of a nondepressor dose of candesartan inhibited the stress-induced pressor response to a greater extent in WKYpch1.0 than in WKY. Intravenous injection of phenylephrine caused a presser effect comparable between WKYpch1.0 and WKY. These results suggest that the chromosome 1 blood pressure QTL congenic rat has a sympathetic hyperreactivity to an air-jet stress, which causes exaggerated pressor responses. The exaggerated response is at least partly mediated by the brain RAS.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stresp23Ratanxiety disorder  IDA  RGD 
SHRSP/IzmRathypertension MODEL: spontaneousIAGP compared to control strain WKY/IzmRGD 
WKY/IzmRathypertension MODEL: controlIAGP compared to hypertensive strain SHRSP/IzmRGD 
SHRSP/IzmRatStress-Induced Hypertension inducedIAGPair-jet exposurecompared to control strain WKY/IzmRGD 
WKY.SHRSP-(D1Wox29-D1Arb21)/IzmRatStress-Induced Hypertension inducedIAGPair-jet exposurecompared to hypertensive strain SHRSP/IzmRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WKY.SHRSP-(D1Wox29-D1Arb21)/IzmRatabnormal renal sympathetic nerve activity inducedIAGPair-jet exposurecompared to hypertensive strain SHRSP/IzmRGD 
SHRSP/IzmRatabnormal response of heart to induced stress inducedIAGPair-jet exposurecompared to control strain WKY/IzmRGD 
SHRSP/IzmRatabnormal systemic arterial blood pressure regulation susceptibilityIAGP compared to control strain WKY/IzmRGD 
WKY/IzmRatdecreased mean systemic arterial blood pressure susceptibilityIAGP compared to hypertensive strain SHRSP/IzmRGD 
WKY/IzmRatdecreased renal sympathetic nerve activity inducedIAGPair-jet exposurecompared to hypertensive strain SHRSP/IzmRGD 
WKY.SHRSP-(D1Wox29-D1Arb21)/IzmRatdecreased susceptibility to hypertension susceptibilityIAGP compared to hypertensive strain SHRSP/IzmRGD 
WKY/IzmRatdecreased susceptibility to hypertension susceptibilityIAGP compared to hypertensive strain SHRSP/IzmRGD 
SHRSP/IzmRathypertension susceptibilityIAGP compared to control strain WKY/IzmRGD 
Stresp23Ratincreased heart rate  IAGP  RGD 
WKY.SHRSP-(D1Wox29-D1Arb21)/IzmRatincreased heart rate  IAGPair-jet exposurecompared to control strain WKY/IzmRGD 
SHRSP/IzmRatincreased mean systemic arterial blood pressure susceptibilityIAGP compared to control strain WKY/IzmRGD 
SHRSP/IzmRatincreased renal sympathetic nerve activity inducedIAGPair-jet exposurecompared to control strain WKY/IzmRGD 
Stresp23Ratincreased renal sympathetic nerve activity  IAGP  RGD 
WKY.SHRSP-(D1Wox29-D1Arb21)/IzmRatincreased renal sympathetic nerve activity  IAGP compared to control strain WKY/IzmRGD 
SHRSP/IzmRatincreased susceptibility to hypertension susceptibilityIAGP compared to control strain WKY/IzmRGD 
Stresp23Ratincreased systemic arterial blood pressure  IAGP  RGD 

Objects Annotated

QTLs
Stresp23  (Stress response QTL 23)

Strains
SHRSP/Izm  (NA)
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm  (NA)
WKY/Izm  (Wistar-Kyoto)


Additional Information