RGD Reference Report - Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain. - Rat Genome Database

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Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain.

Authors: Pandey, J  Gould, KA  McComb, RD  Shull, JD  Wendell, DL 
Citation: Pandey J, etal., Mamm Genome. 2005 Nov;16(11):865-72. Epub 2005 Nov 11.
RGD ID: 1559291
Pubmed: PMID:16284802   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-005-0071-6   (Journal Full-text)

In some rat strains chronic administration of exogenous estrogens induces pyometritis, an inflammation of the uterus associated with infection, suggesting that there is genetic variation in susceptibility to estrogen-induced inflammation and pyometritis. In this article we report that following 10 weeks of treatment with the synthetic estrogen diethylstilbestrol (DES), Fisher 344 (F344) rats exhibit modest uterine inflammation and a 0% incidence of pyometritis. By contrast, under identical experimental conditions, Brown Norway (BN) rats exhibit significant inflammation and a 100% incidence of pyometritis. Similarly, we also observed profound uterine inflammation and a 100% incidence of pyometritis in a congenic rat strain in which a segment of RNO5 from the BN strain is carried on the F344 strain. These data suggest that a locus on RNO5 controls both the magnitude of DES-induced uterine inflammation and susceptibility to DES-induced pyometritis. This locus, designated Eutr2, resides within the same segment of RNO5 as the Eutr1 locus, which confers susceptibility to E2-induced pyometritis in an F2 population generated in a cross between the BN and August x Copenhagen 9935, Irish (ACI) strains.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eutr2Ratbacterial infectious disease  IAGP  RGD 
Eutr2RatInflammation  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eutr2Ratreproductive system inflammation  IAGP  RGD 
Objects Annotated

QTLs
Eutr2  (Estrogen induced uterine response QTL 2)

Objects referenced in this article
Strain F344/NHsd F344/NHsd Rattus norvegicus

Additional Information