RGD Reference Report - Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. - Rat Genome Database

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Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.

Authors: Malechka, Volha V  Moiseyev, Gennadiy  Takahashi, Yusuke  Shin, Younghwa  Ma, Jian-Xing 
Citation: Malechka VV, etal., Am J Pathol. 2017 Oct;187(10):2222-2231. doi: 10.1016/j.ajpath.2017.06.007. Epub 2017 Jul 19.
RGD ID: 155631297
Pubmed: PMID:28734946   (View Abstract at PubMed)
PMCID: PMC5809515   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ajpath.2017.06.007   (Journal Full-text)

Diabetic retinopathy is a common complication of diabetes mellitus. Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and color perception before microvascular pathologies become apparent. Herein, we evaluated early changes in neural retinal function and in retinoid metabolism in the eye in diabetes. Streptozotocin-induced diabetic rats showed decreased a- and b-wave amplitudes of scotopic and photopic electroretinography responses 4 months after diabetes induction compared to nondiabetic controls. Although Western blot analysis revealed no difference in opsin expression, rhodopsin content was decreased in diabetic retinas, as shown by a difference in absorbance. Consistently, levels of 11-cis-retinal, the chromophore for visual pigments, were significantly lower in diabetic retinas compared to those in controls, suggesting a retinoid deficiency. Among visual cycle proteins, interphotoreceptor retinoid-binding protein and stimulated by retinoic acid 6 protein showed significantly lower levels in diabetic rats than those in nondiabetic controls. Similarly, serum levels of retinol-binding protein 4 and retinoids were significantly lower in diabetic rats. Overall, these results suggest that retinoid metabolism in the eye is impaired in type 1 diabetes, which leads to deficient generation of visual pigments and neural retinal dysfunction in early diabetes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
STRA6HumanExperimental Diabetes Mellitus  ISOStra6 (Rattus norvegicus)protein:decreased expression:optic cup (rat)RGD 
Stra6RatExperimental Diabetes Mellitus  IEP protein:decreased expression:optic cup (rat)RGD 
Stra6MouseExperimental Diabetes Mellitus  ISOStra6 (Rattus norvegicus)protein:decreased expression:optic cup (rat)RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
STRA6Human4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression ISOStra6 (Rattus norvegicus)Am580 increases expression of Stra6 mRNA in lungRGD 
Stra6Rat4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression EXP Am580 increases expression of Stra6 mRNA in lungRGD 
Stra6Mouse4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression ISOStra6 (Rattus norvegicus)Am580 increases expression of Stra6 mRNA in lungRGD 
STRA6Humanall-trans-retinoic acid increases expression ISOStra6 (Rattus norvegicus)All-trans-retinoic acid increases expression of Stra6 mRNA in lungRGD 
Stra6Ratall-trans-retinoic acid increases expression EXP All-trans-retinoic acid increases expression of Stra6 mRNA in lungRGD 
Stra6Mouseall-trans-retinoic acid increases expression ISOStra6 (Rattus norvegicus)All-trans-retinoic acid increases expression of Stra6 mRNA in lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Stra6  (signaling receptor and transporter of retinol STRA6)

Genes (Mus musculus)
Stra6  (stimulated by retinoic acid gene 6)

Genes (Homo sapiens)
STRA6  (signaling receptor and transporter of retinol STRA6)


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