RGD Reference Report - Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion. - Rat Genome Database

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Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion.

Authors: Johnston, Jermaine G  Speed, Joshua S  Becker, Bryan K  Kasztan, Malgorzata  Soliman, Reham H  Rhoads, Megan K  Tao, Binli  Jin, Chunhua  Geurts, Aron M  Hyndman, Kelly A  Pollock, Jennifer S  Pollock, David M 
Citation: Johnston JG, etal., Hypertension. 2020 Jun;75(6):1624-1634. doi: 10.1161/HYPERTENSIONAHA.119.13908. Epub 2020 Apr 20.
RGD ID: 155598602
Pubmed: PMID:32306766   (View Abstract at PubMed)
PMCID: PMC7228023   (View Article at PubMed Central)
DOI: DOI:10.1161/HYPERTENSIONAHA.119.13908   (Journal Full-text)

The diurnal rhythms of sodium handling and blood pressure are thought to be regulated by clock genes, such as Bmal1. However, little is known about the regulation of these factors by Bmal1, especially in rats. Using a novel whole-body Bmal1 knockout rat model (Bmal1-/-), we hypothesized that time of day regulation of sodium excretion is dependent on Bmal1. Using telemetry to continuously record mean arterial pressure, we observed that male and female Bmal1-/- rats had significantly reduced mean arterial pressure over the course of 24 hours compared with littermate controls. The circadian mean arterial pressure pattern remained intact in both sexes of Bmal1-/- rats, which is in contrast to the Bmal1-/- mouse model. Male Bmal1-/- rats had no significant difference in baseline sodium excretion between 12-hour active and inactive periods, indicating a lack of diurnal control independent of maintained mean arterial pressure rhythms. Female Bmal1-/- rats, however, had significantly greater sodium excretion during the active versus inactive period similar to controls. Thus, we observed a clear dissociation between circadian blood pressure and control of sodium excretion that is sex dependent. These findings are consistent with a more robust ability of females to maintain control of sodium excretion, and furthermore, demonstrate a novel role for Bmal1 in control of diurnal blood pressure independent of sodium excretion.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmal1Ratabnormal urine sodium level sex_dimorphismIMP in maleRGD 
Bmal1em1McwiRatabnormal urine sodium level sex_dimorphismIMP in maleRGD 
SD-Bmal1em1McwiRatabnormal urine sodium level sex_dimorphismIMP in maleRGD 
Bmal1Ratdecreased body weight  IMP compared to wild typeRGD 
Bmal1em1McwiRatdecreased body weight  IMP compared to wild typeRGD 
SD-Bmal1em1McwiRatdecreased body weight  IMP compared to wild typeRGD 
Bmal1Ratdecreased food intake  IMP compared to wild typeRGD 
Bmal1em1McwiRatdecreased food intake  IMP compared to wild typeRGD 
SD-Bmal1em1McwiRatdecreased food intake  IMP compared to wild typeRGD 
Bmal1Ratdecreased mean systemic arterial blood pressure  IMP compared to wild typeRGD 
Bmal1em1McwiRatdecreased mean systemic arterial blood pressure  IMP compared to wild typeRGD 
SD-Bmal1em1McwiRatdecreased mean systemic arterial blood pressure  IMP compared to wild typeRGD 
Bmal1Ratdecreased systemic arterial diastolic blood pressure  IMP compared to wild typeRGD 
Bmal1em1McwiRatdecreased systemic arterial diastolic blood pressure  IMP compared to wild typeRGD 
SD-Bmal1em1McwiRatdecreased systemic arterial diastolic blood pressure  IMP compared to wild typeRGD 
Bmal1Ratdecreased systemic arterial systolic blood pressure  IMP compared to wild typeRGD 
Bmal1em1McwiRatdecreased systemic arterial systolic blood pressure  IMP compared to wild typeRGD 
SD-Bmal1em1McwiRatdecreased systemic arterial systolic blood pressure  IMP compared to wild typeRGD 
Bmal1Ratincreased heart rate sexual_dimorphism IMP in femaleRGD 
Bmal1em1McwiRatincreased heart rate sexual_dimorphism IMP in femaleRGD 
SD-Bmal1em1McwiRatincreased heart rate sexual_dimorphism IMP in femaleRGD 
Objects Annotated

Genes (Rattus norvegicus)
Bmal1  (basic helix-loop-helix ARNT like 1)
Bmal1em1Mcwi  (basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi)

Strains
SD-Bmal1em1Mcwi  (NA)


Additional Information