RGD Reference Report - A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. - Rat Genome Database

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A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia.

Authors: Smalla, K-H  Mikhaylova, M  Sahin, J  Bernstein, H-G  Bogerts, B  Schmitt, A  van der Schors, R  Smit, A B  Li, K W  Gundelfinger, E D  Kreutz, M R 
Citation: Smalla KH, etal., Mol Psychiatry. 2008 Sep;13(9):878-96. doi: 10.1038/mp.2008.60. Epub 2008 May 27.
RGD ID: 155230736
Pubmed: PMID:18504422   (View Abstract at PubMed)
DOI: DOI:10.1038/mp.2008.60   (Journal Full-text)

Many studies in recent years suggest that schizophrenia is a synaptic disease that crucially involves a hypofunction of N-methyl-D-aspartate receptor-mediated signaling. However, at present it is unclear how these pathological processes are reflected in the protein content of the synapse. We have employed two-dimensional gel electrophoresis in conjunction with mass spectrometry to characterize and compare the synaptic proteomes of the human left dorsolateral prefrontal cortex in chronic schizophrenia and of the cerebral cortex of rats treated subchronically with ketamine. We found consistent changes in the synaptic proteomes of human schizophrenics and in rats with induced ketamine psychosis compared to controls. However, commonly regulated proteins between both groups were very limited and only prohibitin was found upregulated in both chronic schizophrenia and the rat ketamine model. Prohibitin, however, could be a new potential marker for the synaptic pathology of schizophrenia and might be causally involved in the disease process.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Phb1Ratglutamatergic synapse is_active_inIDA PMID:18504422SynGO 
Phb1Ratsynapse is_active_inIDA PMID:18504422SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Phb1  (prohibitin 1)


Additional Information