RGD Reference Report - Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.

Authors: Ko, MS  Threat, TA  Wang, X  Horton, JH  Cui, Y  Wang, X  Pryor, E  Paris, J  Wells-Smith, J  Kitchen, JR  Rowe, LB  Eppig, J  Satoh, T  Brant, L  Fujiwara, H  Yotsumoto, S  Nakashima, H 
Citation: Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
RGD ID: 1549468
Pubmed: PMID:9811942   (View Abstract at PubMed)

Mammalian embryos can only survive if they attach to the uterus (implantation) and establish proper maternal-fetal interactions. To understand this complex implantation pathway, we have initiated genomic analysis with a systematic study of the cohort of genes expressed in extraembryonic cells that are derived from the conceptus and play a major role in this process. A total of 2103 cDNAs from the extraembryonic portion of 7.5-day post-conception mouse embryos yielded 3186 expressed sequence tags, approximately 40% of which were novel to the sequence databases. Furthermore, when 155 of the cDNA clones with no homology to previously detected genes were genetically mapped, apparent clustering of these expressed genes was detected in subregions of chromosomes 2, 7, 9 and 17, with 6.5% of the observed genes localized in the t-complex region of chromosome 17, which represents only approximately 1.5% of the mouse genome. In contrast, X-linked genes were under-represented. Semi-quantitative RT-PCR analyses of the mapped genes demonstrated that one third of the genes were expressed solely in extraembryonic tissue and an additional one third of the genes were expressed predominantly in the extraembryonic tissues. The over-representation of extraembryonic-expressed genes in dosage-sensitive autosomal imprinted regions and under-representation on the dosage-compensated X chromosome may reflect a need for tight quantitative control of expression during development.



Objects referenced in this article
Gene Abcf1 ATP-binding cassette, sub-family F member 1 Mus musculus
Gene Acat1 acetyl-Coenzyme A acetyltransferase 1 Mus musculus
Gene Acat2 acetyl-Coenzyme A acetyltransferase 2 Mus musculus
Gene Aco2 aconitase 2, mitochondrial Mus musculus
Gene Actg1 actin, gamma, cytoplasmic 1 Mus musculus
Gene Adm adrenomedullin Mus musculus
Gene Agtrap angiotensin II, type I receptor-associated protein Mus musculus
Gene Aldh7a1 aldehyde dehydrogenase family 7, member A1 Mus musculus
Gene Ass1 argininosuccinate synthetase 1 Mus musculus
Gene Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus
Gene Atp5f1a ATP synthase F1 subunit alpha Mus musculus
Gene Atp5f1b ATP synthase F1 subunit beta Mus musculus
Gene Atp5po ATP synthase peripheral stalk subunit OSCP Mus musculus
Gene Bex3 brain expressed X-linked 3 Mus musculus
Gene Bmp6 bone morphogenetic protein 6 Mus musculus
Gene C1qbp complement component 1, q subcomponent binding protein Mus musculus
Gene Calm1 calmodulin 1 Mus musculus
Gene Cdc42 cell division cycle 42 Mus musculus
Gene Cdh5 cadherin 5 Mus musculus
Gene Cds2 CDP-diacylglycerol synthase 2 Mus musculus
Gene Ceacam9 CEA cell adhesion molecule 9 Mus musculus
Gene Celf1 CUGBP, Elav-like family member 1 Mus musculus
Gene Cherp calcium homeostasis endoplasmic reticulum protein Mus musculus
Gene Clcn7 chloride channel, voltage-sensitive 7 Mus musculus
Gene Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit Mus musculus
Gene Cnbp cellular nucleic acid binding protein Mus musculus
Gene Comt catechol-O-methyltransferase Mus musculus
Gene Cops7b COP9 signalosome subunit 7B Mus musculus
Gene Ctnna1 catenin alpha 1 Mus musculus
Gene Cubn cubilin Mus musculus
Gene Dab2 disabled 2, mitogen-responsive phosphoprotein Mus musculus
Gene Dag1 dystroglycan 1 Mus musculus
Gene Dbt dihydrolipoamide branched chain transacylase E2 Mus musculus
Gene Ddx21 DExD box helicase 21 Mus musculus
Gene Ddx5 DEAD box helicase 5 Mus musculus
Gene Diaph1 diaphanous related formin 1 Mus musculus
Gene Dock9 dedicator of cytokinesis 9 Mus musculus
Gene Eef2 eukaryotic translation elongation factor 2 Mus musculus
Gene Efhd2 EF hand domain containing 2 Mus musculus
Gene Eif3b eukaryotic translation initiation factor 3, subunit B Mus musculus
Gene Eif4e eukaryotic translation initiation factor 4E Mus musculus
Gene Eif4e2 eukaryotic translation initiation factor 4E member 2 Mus musculus
Gene Eif4g2 eukaryotic translation initiation factor 4, gamma 2 Mus musculus
Gene Eif5a eukaryotic translation initiation factor 5A Mus musculus
Gene Elac2 elaC ribonuclease Z 2 Mus musculus
Gene Emb embigin Mus musculus
Gene Eno1 enolase 1, alpha non-neuron Mus musculus
Gene Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 Mus musculus
Gene Exosc5 exosome component 5 Mus musculus
Gene Folr1 folate receptor alpha Mus musculus
Gene Folr2 folate receptor beta Mus musculus
Gene Ftl1 ferritin light polypeptide 1 Mus musculus
Gene Gclc glutamate-cysteine ligase, catalytic subunit Mus musculus
Gene Gfm1 G elongation factor, mitochondrial 1 Mus musculus
Gene Gjb3 gap junction protein, beta 3 Mus musculus
Gene Glrx glutaredoxin Mus musculus
Gene Gnb1 guanine nucleotide binding protein (G protein), beta 1 Mus musculus
Gene Gnb3 guanine nucleotide binding protein (G protein), beta 3 Mus musculus
Gene Gnb5 guanine nucleotide binding protein (G protein), beta 5 Mus musculus
Gene Grsf1 G-rich RNA sequence binding factor 1 Mus musculus
Gene Gsn gelsolin Mus musculus
Gene Gtf2h5 general transcription factor IIH, polypeptide 5 Mus musculus
Gene Hadh hydroxyacyl-Coenzyme A dehydrogenase Mus musculus
Gene Hdac2 histone deacetylase 2 Mus musculus
Gene Hmox1 heme oxygenase 1 Mus musculus
Gene Hmox2 heme oxygenase 2 Mus musculus
Gene Hnrnpc heterogeneous nuclear ribonucleoprotein C Mus musculus
Gene Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like Mus musculus
Gene Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 Mus musculus
Gene Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 Mus musculus
Gene Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 Mus musculus
Gene Hsp90b1 heat shock protein 90, beta (Grp94), member 1 Mus musculus
Gene Hspa4 heat shock protein 4 Mus musculus
Gene Hspa5 heat shock protein 5 Mus musculus
Gene Hspa8 heat shock protein 8 Mus musculus
Gene Id1 inhibitor of DNA binding 1, HLH protein Mus musculus
Gene Il2rg interleukin 2 receptor, gamma chain Mus musculus
Gene Imp4 IMP4, U3 small nucleolar ribonucleoprotein Mus musculus
Gene Ing4 inhibitor of growth family, member 4 Mus musculus
Gene Itgb4 integrin beta 4 Mus musculus
Gene Kars1 lysyl-tRNA synthetase 1 Mus musculus
Gene Kat14 lysine acetyltransferase 14 Mus musculus
Gene Krt18 keratin 18 Mus musculus
Gene Krt19 keratin 19 Mus musculus
Gene Krt7 keratin 7 Mus musculus
Gene Lama5 laminin, alpha 5 Mus musculus
Gene Larp4b La ribonucleoprotein 4B Mus musculus
Gene Lcat lecithin cholesterol acyltransferase Mus musculus
Gene Ldha lactate dehydrogenase A Mus musculus
Gene Lgals1 lectin, galactose binding, soluble 1 Mus musculus
Gene Lig3 ligase III, DNA, ATP-dependent Mus musculus
Gene Liph lipase, member H Mus musculus
Gene Ltb lymphotoxin B Mus musculus
Gene Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 Mus musculus
Gene Mcm6 minichromosome maintenance complex component 6 Mus musculus
Gene Mdh2 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus
Gene Mepce methylphosphate capping enzyme Mus musculus
Gene Mlph melanophilin Mus musculus
Gene Mrpl21 mitochondrial ribosomal protein L21 Mus musculus
Gene Msrb1 methionine sulfoxide reductase B1 Mus musculus
Gene Myadm myeloid-associated differentiation marker Mus musculus
Gene Nap1l4 nucleosome assembly protein 1-like 4 Mus musculus
Gene Ncl nucleolin Mus musculus
Gene Nfe2l1 nuclear factor, erythroid derived 2,-like 1 Mus musculus
Gene Npm1 nucleophosmin 1 Mus musculus
Gene Nsun2 NOL1/NOP2/Sun domain family member 2 Mus musculus
Gene Nubp2 nucleotide binding protein 2 Mus musculus
Gene Pabpc1 poly(A) binding protein, cytoplasmic 1 Mus musculus
Gene Pea15a proliferation and apoptosis adaptor protein 15A Mus musculus
Gene Pkm pyruvate kinase, muscle Mus musculus
Gene Pknox1 Pbx/knotted 1 homeobox Mus musculus
Gene Plac8 placenta-specific 8 Mus musculus
Gene Polr1f RNA polymerase I subunit F Mus musculus
Gene Ppia peptidylprolyl isomerase A Mus musculus
Gene Ppib peptidylprolyl isomerase B Mus musculus
Gene Ppic peptidylprolyl isomerase C Mus musculus
Gene Prep prolyl endopeptidase Mus musculus
Gene Prl3d1 prolactin family 3, subfamily d, member 1 Mus musculus
Gene Prpf19 pre-mRNA processing factor 19 Mus musculus
Gene Psmb2 proteasome (prosome, macropain) subunit, beta type 2 Mus musculus
Gene Ptma prothymosin alpha Mus musculus
Gene Rab7 RAB7, member RAS oncogene family Mus musculus
Gene Rangap1 RAN GTPase activating protein 1 Mus musculus
Gene Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor Mus musculus
Gene Rcor1 REST corepressor 1 Mus musculus
Gene Rhox5 reproductive homeobox 5 Mus musculus
Gene Rpl19 ribosomal protein L19 Mus musculus
Gene Rpl28 ribosomal protein L28 Mus musculus
Gene Rpl37a ribosomal protein L37a Mus musculus
Gene Rpl5 ribosomal protein L5 Mus musculus
Gene Rpl6 ribosomal protein L6 Mus musculus
Gene Rpl9 ribosomal protein L9 Mus musculus
Gene Rpn1 ribophorin I Mus musculus
Gene Rps15 ribosomal protein S15 Mus musculus
Gene Rps18 ribosomal protein S18 Mus musculus
Gene Rps4x ribosomal protein S4, X-linked Mus musculus
Gene Rps6 ribosomal protein S6 Mus musculus
Gene Rrp9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Mus musculus
Gene Scp2 sterol carrier protein 2, liver Mus musculus
Gene Sct secretin Mus musculus
Gene Sdc1 syndecan 1 Mus musculus
Gene Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 Mus musculus
Gene Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus
Gene Slc35c2 solute carrier family 35, member C2 Mus musculus
Gene Smad4 SMAD family member 4 Mus musculus
Gene Soat2 sterol O-acyltransferase 2 Mus musculus
Gene Spg21 SPG21, maspardin Mus musculus
Gene Srsf2 serine and arginine-rich splicing factor 2 Mus musculus
Gene Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit Mus musculus
Gene Surf6 surfeit gene 6 Mus musculus
Gene Tapbp TAP binding protein Mus musculus
Gene Tars1 threonyl-tRNA synthetase 1 Mus musculus
Gene Tfap2c transcription factor AP-2, gamma Mus musculus
Gene Tkt transketolase Mus musculus
Gene Tmem30a transmembrane protein 30A Mus musculus
Gene Tmsb10 thymosin beta 10 Mus musculus
Gene Tomm70a translocase of outer mitochondrial membrane 70A Mus musculus
Gene Tpm3 tropomyosin 3, gamma Mus musculus
Gene Trim36 tripartite motif-containing 36 Mus musculus
Gene Tuba1c tubulin, alpha 1C Mus musculus
Gene Txndc5 thioredoxin domain containing 5 Mus musculus
Gene Ubb ubiquitin B Mus musculus
Gene Ubtf upstream binding transcription factor, RNA polymerase I Mus musculus
Gene Usp39 ubiquitin specific peptidase 39 Mus musculus
Gene Usp9x ubiquitin specific peptidase 9, X chromosome Mus musculus
Gene Vac14 Vac14 homolog (S. cerevisiae) Mus musculus
Gene Vkorc1 vitamin K epoxide reductase complex, subunit 1 Mus musculus
Gene Wdr1 WD repeat domain 1 Mus musculus
Gene Wnt6 wingless-type MMTV integration site family, member 6 Mus musculus
Gene Yipf3 Yip1 domain family, member 3 Mus musculus
Gene Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Mus musculus
Gene Zbtb20 zinc finger and BTB domain containing 20 Mus musculus
Gene Zmym6 zinc finger, MYM-type 6 Mus musculus
Gene Zranb1 zinc finger, RAN-binding domain containing 1 Mus musculus

Additional Information