RGD Reference Report - Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy. - Rat Genome Database

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Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy.

Authors: Hong, Seong-Ho  Chang, Seung-Hee  Cho, Kyung-Cho  Kim, Sanghwa  Park, Sungjin  Lee, Ah Young  Jiang, Hu-Lin  Kim, Hyeon-Jeong  Lee, Somin  Yu, Kyeong-Nam  Seo, Hwi Won  Chae, Chanhee  Kim, Kwang Pyo  Park, Jongsun  Cho, Myung-Haing 
Citation: Hong SH, etal., Oncotarget. 2016 Oct 4;7(40):65335-65347. doi: 10.18632/oncotarget.11678.
RGD ID: 153323314
Pubmed: PMID:27588471   (View Abstract at PubMed)
PMCID: PMC5323159   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.11678   (Journal Full-text)

Trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus is elevated in cancer cells. Therefore, proteins of the ER-Golgi intermediate compartment (ERGIC) attract significant attention as targets for cancer treatment. Enhanced cancer cell growth and epithelial-mesenchymal transition by ERGICs correlates with poor-prognosis of lung cancer. This prompted us to assess whether knockdown of ERGIC3 may decrease lung cancer growth. To test the hypothesis, the effects of ERGIC3 short hairpin RNA (shERGIC3) on ER stress-induced cell death and lung tumorigenesis were investigated both in vitro and in vivo. Knockdown of ERGIC3 led to ER stress-induced autophagic cell death and suppression of proliferation in the A549 human lung cancer cell-line. Moreover, non-invasive aerosol-delivery of shERGIC3 using the biocompatible carrier glycerol propoxylate triacrylate and spermine (GPT-SPE) inhibited lung tumorigenesis in the K-rasLA1 murine model of lung cancer. Our data suggest that suppression of ERGIC3 could provide a framework for the development of effective lung cancer therapies.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ERGIC3Humanlung adenocarcinoma amelioratesISOErgic3 (Mus musculus) RGD 
Ergic3Ratlung adenocarcinoma amelioratesISOErgic3 (Mus musculus) RGD 
Ergic3Mouselung adenocarcinoma amelioratesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ergic3  (ERGIC and golgi 3)

Genes (Mus musculus)
Ergic3  (ERGIC and golgi 3)

Genes (Homo sapiens)
ERGIC3  (ERGIC and golgi 3)


Additional Information