RGD Reference Report - Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors.

Authors: Mitsuishi, Tsuyoshi  Iwabu, Yukie  Tokunaga, Kenzo  Sata, Tetsutaro  Kaneko, Takehiko  Ohara, Kuniaki  Ohsawa, Ikuroh  Oda, Fumino  Yamada, Yuko  Kawana, Seiji  Ozaki, Kohji  Nakatake, Mayuka  Yamada, Osamu 
Citation: Mitsuishi T, etal., BMC Cancer. 2010 Mar 27;10:118. doi: 10.1186/1471-2407-10-118.
RGD ID: 152998971
Pubmed: PMID:20346172   (View Abstract at PubMed)
PMCID: PMC2868050   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2407-10-118   (Journal Full-text)


BACKGROUND: The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular proliferation and regulation of apoptosis in HPV associated anogenital tumors.
METHODS: We investigated the levels of telomerase activity, and inhibitor of apoptosis proteins (IAPs) family (c-IAP1, c-IAP2, XIAP) and c-Myc mRNA expression levels in 20 specimens of Bowenoid papulosis and 36 specimens of condyloma acuminatum in anogenital areas. Overall, phosphorylated (p-) AKT, p-ribosomal protein S6 (S6) and p-4E-binding protein 1 (4EBP1) expression levels were examined by immunohistochemistry in anogenital tumors both with and without positive telomerase activity.
RESULTS: Positive telomerase activity was detected in 41.7% of Bowenoid papulosis and 27.3% of condyloma acuminatum compared to normal skin (p < 0.001). In contrast, the expression levels of Bowenoid papulosis indicated that c-IAP1, c-IAP2 and XIAP mRNA were significantly upregulated compared to those in both condyloma acuminatum samples (p < 0.001, p < 0.001, p = 0.022, respectively) and normal skin (p < 0.001, p = 0.002, p = 0.034, respectively). Overall, 30% of Bowenoid papulosis with high risk HPV strongly promoted IAPs family and c-Myc but condyloma acuminatum did not significantly activate those genes. Immunohistochemically, p-Akt and p-S6 expressions were associated with positive telomerase activity but not with p-4EBP1 expression.
CONCLUSION: Combined analysis of the IAPs family, c-Myc mRNA expression, telomerase activity levels and p-Akt/p-S6 expressions may provide clinically relevant molecular markers in HPV associated anogenital tumors.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BIRC2Humanbowenoid papulosis  IEP mRNA:increased expression:perianal skin (human)RGD 
BIRC3Humanbowenoid papulosis  IEP mRNA:increased expression:perianal skin (human)RGD 
Birc2Ratbowenoid papulosis  ISOBIRC2 (Homo sapiens)mRNA:increased expression:perianal skin (human)RGD 
Birc2Mousebowenoid papulosis  ISOBIRC2 (Homo sapiens)mRNA:increased expression:perianal skin (human)RGD 
Birc3Ratbowenoid papulosis  ISOBIRC3 (Homo sapiens)mRNA:increased expression:perianal skin (human)RGD 
Birc3Mousebowenoid papulosis  ISOBIRC3 (Homo sapiens)mRNA:increased expression:perianal skin (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Birc2  (baculoviral IAP repeat-containing 2)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Mus musculus)
Birc2  (baculoviral IAP repeat-containing 2)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Homo sapiens)
BIRC2  (baculoviral IAP repeat containing 2)
BIRC3  (baculoviral IAP repeat containing 3)


Additional Information