RGD Reference Report - Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. - Rat Genome Database

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Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.

Authors: Hughes, David J  Kunická, Tereza  Schomburg, Lutz  Liška, Václav  Swan, Niall  Souček, Pavel 
Citation: Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
RGD ID: 151665806
Pubmed: PMID:30469315   (View Abstract at PubMed)
PMCID: PMC6266908   (View Article at PubMed Central)
DOI: DOI:10.3390/nu10111812   (Journal Full-text)

Dietary selenium (Se) intake is essential for synthesizing selenoproteins that are important in countering oxidative and inflammatory processes linked to colorectal carcinogenesis. However, there is limited knowledge on the selenoprotein expression in colorectal adenoma (CRA) and colorectal cancer (CRC) patients, or the interaction with Se status levels. We studied the expression of seventeen Se pathway genes (including fifteen of the twenty-five human selenoproteins) in RNA extracted from disease-normal colorectal tissue pairs, in the discovery phase of sixty-two CRA/CRC patients from Ireland and a validation cohort of a hundred and five CRC patients from the Czech Republic. Differences in transcript levels between the disease and paired control mucosa were assessed by the Mann-Whitney U-test. GPX2 and TXNRD3 showed a higher expression and GPX3, SELENOP, SELENOS, and SEPHS2 exhibited a lower expression in the disease tissue from adenomas and both cancer groups (p-values from 0.023 to <0.001). In the Czech cohort, up-regulation of GPX1, SELENOH, and SOD2 and down-regulation of SELENBP1, SELENON, and SELENOK (p-values 0.036 to <0.001) was also observed. We further examined the correlation of gene expression with serum Se status (assessed by Se and selenoprotein P, SELENOP) in the Irish patients. While there were no significant correlations with both Se status markers, SELENOF, SELENOK, and TXNRD1 tumor tissue expression positively correlated with Se, while TXNRD2 and TXNRD3 negatively correlated with SELENOP. In an analysis restricted to the larger Czech CRC patient cohort, Cox regression showed no major association of transcript levels with patient survival, except for an association of higher SELENOF gene expression with both a lower disease-free and overall survival. Several selenoproteins were differentially expressed in the disease tissue compared to the normal tissue of both CRA and CRC patients. Altered selenoprotein expression may serve as a marker of functional Se status and colorectal adenoma to cancer progression.



Disease Annotations    Click to see Annotation Detail View
RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX2Humancolorectal adenoma  IEP mRNA:increased expression:colorectum (human)RGD 
GPX3Humancolorectal adenoma  IEP mRNA:decreased expression:colorectum (human)RGD 
Gpx2Ratcolorectal adenoma  ISOGPX2 (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
Gpx2Mousecolorectal adenoma  ISOGPX2 (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
Gpx3Ratcolorectal adenoma  ISOGPX3 (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
Gpx3Mousecolorectal adenoma  ISOGPX3 (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SELENOHHumancolorectal adenoma  IEP mRNA:increased expression:colorectum (human)RGD 
SELENOPHumancolorectal adenoma  IEP mRNA:decreased expression:colorectum (human)RGD 
SELENOSHumancolorectal adenoma  IEP mRNA:decreased expression:colorectum (human) RGD 
SEPHS2Humancolorectal adenoma  IEP mRNA:decreased expression:colorectum (human) RGD 
SelenohRatcolorectal adenoma  ISOSELENOH (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
SelenohMousecolorectal adenoma  ISOSELENOH (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
SelenopRatcolorectal adenoma  ISOSELENOP (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SelenopMousecolorectal adenoma  ISOSELENOP (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SelenosRatcolorectal adenoma  ISOSELENOS (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
SelenosMousecolorectal adenoma  ISOSELENOS (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
Sephs2Ratcolorectal adenoma  ISOSEPHS2 (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
Sephs2Mousecolorectal adenoma  ISOSEPHS2 (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
TXNRD3Humancolorectal adenoma  IEP mRNA:increased expression:colorectum (human) RGD 
Txnrd3Ratcolorectal adenoma  ISOTXNRD3 (Homo sapiens)mRNA:increased expression:colorectum (human) RGD 
Txnrd3Mousecolorectal adenoma  ISOTXNRD3 (Homo sapiens)mRNA:increased expression:colorectum (human) RGD 
GPX2Humancolorectal carcinoma  IEP mRNA:increased expression:colorectum (human)RGD 
GPX3Humancolorectal carcinoma  IEP mRNA:decreased expression:colorectum (human)RGD 
Gpx2Mousecolorectal carcinoma  ISOGPX2 (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
Gpx2Ratcolorectal carcinoma  ISOGPX2 (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
Gpx3Mousecolorectal carcinoma  ISOGPX3 (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
Gpx3Ratcolorectal carcinoma  ISOGPX3 (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SELENOHHumancolorectal carcinoma  IEP mRNA:increased expression:colorectum (human)RGD 
SELENOPHumancolorectal carcinoma  IEP mRNA:decreased expression:colorectum (human)RGD 
SELENOSHumancolorectal carcinoma  IEP mRNA:decreased expression:colorectum (human) RGD 
SEPHS2Humancolorectal carcinoma  IEP mRNA:decreased expression:colorectum (human) RGD 
SelenohMousecolorectal carcinoma  ISOSELENOH (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
SelenohRatcolorectal carcinoma  ISOSELENOH (Homo sapiens)mRNA:increased expression:colorectum (human)RGD 
SelenopMousecolorectal carcinoma  ISOSELENOP (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SelenopRatcolorectal carcinoma  ISOSELENOP (Homo sapiens)mRNA:decreased expression:colorectum (human)RGD 
SelenosMousecolorectal carcinoma  ISOSELENOS (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
SelenosRatcolorectal carcinoma  ISOSELENOS (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
Sephs2Mousecolorectal carcinoma  ISOSEPHS2 (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
Sephs2Ratcolorectal carcinoma  ISOSEPHS2 (Homo sapiens)mRNA:decreased expression:colorectum (human) RGD 
TXNRD3Humancolorectal carcinoma  IEP mRNA:increased expression:colorectum (human) RGD 
Txnrd3Ratcolorectal carcinoma  ISOTXNRD3 (Homo sapiens)mRNA:increased expression:colorectum (human) RGD 
Txnrd3Mousecolorectal carcinoma  ISOTXNRD3 (Homo sapiens)mRNA:increased expression:colorectum (human) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx2  (glutathione peroxidase 2)
Gpx3  (glutathione peroxidase 3)
Selenoh  (selenoprotein H)
Selenop  (selenoprotein P)
Selenos  (selenoprotein S)
Sephs2  (selenophosphate synthetase 2)
Txnrd3  (thioredoxin reductase 3)

Genes (Mus musculus)
Gpx2  (glutathione peroxidase 2)
Gpx3  (glutathione peroxidase 3)
Selenoh  (selenoprotein H)
Selenop  (selenoprotein P)
Selenos  (selenoprotein S)
Sephs2  (selenophosphate synthetase 2)
Txnrd3  (thioredoxin reductase 3)

Genes (Homo sapiens)
GPX2  (glutathione peroxidase 2)
GPX3  (glutathione peroxidase 3)
SELENOH  (selenoprotein H)
SELENOP  (selenoprotein P)
SELENOS  (selenoprotein S)
SEPHS2  (selenophosphate synthetase 2)
TXNRD3  (thioredoxin reductase 3)


Additional Information