RGD Reference Report - Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion. - Rat Genome Database

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Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion.

Authors: Rassenti, L Z  Kipps, T J 
Citation: Rassenti LZ and Kipps TJ, Blood. 2000 Apr 15;95(8):2725-7.
RGD ID: 151665152
Pubmed: PMID:10753858   (View Abstract at PubMed)

Because immunoglobulin (Ig)-beta (CD79b) is required for immunoglobulin allelic exclusion, we examined the CD79b expressed by four chronic lymphocytic leukemia (CLL) samples that expressed more than one immunoglobulin heavy-chain allele and five samples that had normal immunoglobulin heavy-chain allelic exclusion. All leukemia cell samples stained poorly with monoclonal antibodies specific for extracellular epitopes of CD79b. However, all samples expressed functional CD79b genes, regardless of whether they did or did not express more than one immunoglobulin heavy-chain allele. We identified variant CD79b genes that had conservative base substitutions restricted to regions encoding the extracellular immunoglobulin-like domain of CD79b. However, these variants were not restricted to samples lacking immunoglobulin heavy-chain allelic exclusion and most likely reflect genetic polymorphism. Collectively, these data indicate that the unusual expression of more than one immunoglobulin heavy allele by CLL B cells is not associated with structural, nonconservative mutations in the signal-transduction domains of CD79b. (Blood. 2000;95:2725-2727)



Disease Annotations    Click to see Annotation Detail View
RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD79BHumanchronic lymphocytic leukemia  IAGP DNA:mutation:multiple (human)RGD 
CD79BHumanchronic lymphocytic leukemia  IEP protein:decreased expression:blood cells (human)RGD 
Cd79bRatchronic lymphocytic leukemia  ISOCD79B (Homo sapiens)protein:decreased expression:blood cells (human)RGD 
Cd79bMousechronic lymphocytic leukemia  ISOCD79B (Homo sapiens)protein:decreased expression:blood cells (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd79b  (CD79b molecule)

Genes (Mus musculus)
Cd79b  (CD79B antigen)

Genes (Homo sapiens)
CD79B  (CD79b molecule)


Additional Information