RGD Reference Report - SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer. - Rat Genome Database

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SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer.

Authors: Han, Fei  Liu, Wen-Bin  Shi, Xiao-Yan  Yang, Jun-Tang  Zhang, Xi  Li, Zhi-Ming  Jiang, Xiao  Yin, Li  Li, Jian-Jun  Huang, Chuan-Shu  Cao, Jia  Liu, Jin-Yi 
Citation: Han F, etal., EBioMedicine. 2018 May;31:253-266. doi: 10.1016/j.ebiom.2018.04.026. Epub 2018 May 5.
RGD ID: 151660333
Pubmed: PMID:29739711   (View Abstract at PubMed)
PMCID: PMC6014586   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ebiom.2018.04.026   (Journal Full-text)

Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism of this metastasis remains unclear. Here, we investigate in lung cancer that SOX30 is sharply under-expressed in metastatic tumors compared with non-metastatic tumors, and suppresses plenty of metastasis related processes or pathways. SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo. Sox30 deficiency promotes lung metastasis in Sox30-/- mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression. Mechanistically, SOX30 diminishes Wnt-signaling via directly transcriptional repressing β-catenin or interacting with β-catenin to compete with TCF for binding to β-catenin. The carboxyl-terminus of SOX30 is required for attenuating β-catenin transcriptional activity, whereas the amino-terminus of SOX30 is required for its interaction with β-catenin protein. Enhance of β-catenin attenuates the anti-metastatic role of SOX30. Moreover, Sox30 deficiency promotes tumor metastasis and reduces survival of mice. In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients. Altogether, these results highlight an important role and mechanism of SOX30 in lung cancer metastasis, providing a potential therapeutic target for anti-metastasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SOX30HumanLiver Metastasis amelioratesISOSox30 (Mus musculus) RGD 
Sox30MouseLiver Metastasis amelioratesIDA  RGD 
Sox30RatLiver Metastasis amelioratesISOSox30 (Mus musculus) RGD 
SOX30Humanlung metastasis amelioratesISOSox30 (Mus musculus) RGD 
Sox30Mouselung metastasis amelioratesIDA  RGD 
Sox30Ratlung metastasis amelioratesISOSox30 (Mus musculus) RGD 
SOX30HumanNeoplasm Metastasis  IEP associated with lung non-small cell carcinoma more ...RGD 
Sox30MouseNeoplasm Metastasis  ISOSOX30 (Homo sapiens)associated with lung non-small cell carcinoma more ...RGD 
Sox30RatNeoplasm Metastasis  ISOSOX30 (Homo sapiens)associated with lung non-small cell carcinoma more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sox30  (SRY-box transcription factor 30)

Genes (Mus musculus)
Sox30  (SRY (sex determining region Y)-box 30)

Genes (Homo sapiens)
SOX30  (SRY-box transcription factor 30)


Additional Information