RGD Reference Report - Identification of a nuclear receptor for bile acids. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Identification of a nuclear receptor for bile acids.

Authors: Makishima, M  Okamoto, A Y  Repa, J J  Tu, H  Learned, R M  Luk, A  Hull, M V  Lustig, K D  Mangelsdorf, D J  Shan, B 
Citation: Makishima M, etal., Science. 1999 May 21;284(5418):1362-5. doi: 10.1126/science.284.5418.1362.
RGD ID: 15090836
Pubmed: PMID:10334992   (View Abstract at PubMed)
DOI: DOI:10.1126/science.284.5418.1362   (Journal Full-text)

Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nr1h4Ratcellular response to bile acid involved_inIDA PMID:10334992UniProt 
Nr1h4Ratnuclear receptor-mediated bile acid signaling pathway involved_inIDA PMID:10334992UniProt 
Nr1h4Ratregulation of transcription by RNA polymerase II involved_inIDA PMID:10334992UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nr1h4Ratreceptor complex part_ofIDA PMID:10334992UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nr1h4Ratbile acid nuclear receptor activity enablesIDA PMID:10334992UniProt 
Nr1h4Ratchenodeoxycholic acid binding enablesIDA PMID:10334992UniProt 
Nr1h4Ratnuclear receptor activity enablesIDA PMID:10334992UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Nr1h4  (nuclear receptor subfamily 1, group H, member 4)


Additional Information