RGD Reference Report - Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. - Rat Genome Database

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Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.

Authors: Schmale, H  Richter, D 
Citation: Schmale H and Richter D, Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.
RGD ID: 150429658
Pubmed: PMID:6717565   (View Abstract at PubMed)
DOI: DOI:10.1038/308705a0   (Journal Full-text)

In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AVPHumandiabetes insipidus  ISOAvp (Rattus norvegicus)DNA:deletion:cds:exon B (rat)RGD 
AvpRatdiabetes insipidus  IAGP DNA:deletion:cds:exon B (rat)RGD 
AvpMousediabetes insipidus  ISOAvp (Rattus norvegicus)DNA:deletion:cds:exon B (rat)RGD 
AvpdiRatdiabetes insipidus  IAGP DNA:deletion:cds:exon B (rat)RGD 
BRAT-Avpdi/BluHsdRatdiabetes insipidus  IAGP DNA:deletion:cds:exon B (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)
Avpdi  (arginine vasopressin; diabetes insipidus mutant)

Genes (Mus musculus)
Avp  (arginine vasopressin)

Genes (Homo sapiens)
AVP  (arginine vasopressin)

Strains
BRAT-Avpdi/BluHsd  (Brattleboro)


Additional Information