RGD Reference Report - The LEC rat: a model for human hepatitis, liver cancer, and much more. - Rat Genome Database

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The LEC rat: a model for human hepatitis, liver cancer, and much more.

Authors: Mori, M  Hattori, A  Sawaki, M  Tsuzuki, N  Sawada, N  Oyamada, M  Sugawara, N  Enomoto, K 
Citation: Mori M, etal., Am J Pathol. 1994 Jan;144(1):200-4.
RGD ID: 15036817
Pubmed: PMID:8291609   (View Abstract at PubMed)
PMCID: PMC1887108   (View Article at PubMed Central)

The LEC rat is an inbred mutant strain with spontaneous hepatitis isolated from Long-Evans rats. Since approximately 40% of LEC rats die of fulminant hepatitis, the rat serves an animal model for studying the pathogenesis and treatment of human fulminant hepatitis. The remaining 60% of LEC rats survive and develop chronic (prolonged) hepatitis and subsequently develop liver cancer. Therefore, the LEC rat serves an important animal model for studying the significance of chronic hepatitis in the development of human liver cancer, which often develops in association with chronic hepatitis. The LEC rat can also be used as an animal model of Wilson's disease, since recent studies have disclosed high copper accumulation in the liver and low ceruloplasmin concentration in the serum of this mutant rat.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEC/HokRatAcute Liver Failure  IAGP  RGD 
LEC/HokRathepatocellular carcinoma onsetIAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEC/HokRatincreased liver copper level  IAGP  RGD 
Objects Annotated

Strains
LEC/Hok  (Long Evans Cinnamon)

Objects referenced in this article
Gene ATP7B ATPase copper transporting beta Homo sapiens
Gene Atp7b ATPase, copper transporting, beta polypeptide Mus musculus
Gene Atp7b ATPase copper transporting beta Rattus norvegicus
Gene Atp7bhts ATPase copper transporting beta; hepatitis Rattus norvegicus

Additional Information