RGD Reference Report - A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. - Rat Genome Database

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A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.

Authors: Dibra, Denada  Xia, Xueqing  Gagea, Mihai  Lozano, Guillermina  Li, Shulin 
Citation: Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
RGD ID: 14995936
Pubmed: PMID:29494633   (View Abstract at PubMed)
PMCID: PMC5832250   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0193485   (Journal Full-text)

Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking. One of the most accepted animal models for this disease uses HLA-B27/Hu-β2m transgenic rats; however, only 30%-50% of male HLA-B27/Hu-β2m rats develop spontaneous, clinically apparent spondylitis and have a variable time until disease onset. Here, we report a high-incidence, low-variation spontaneous mouse model that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs. In this human disease-like mouse model, bone loss and pathogenic bone development are seen as early as 4 months of age in the absence of inflammatory aggregates in the enthesis or intervertebral disc.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Il27  (interleukin 27)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
IL27  (interleukin 27)
TP53  (tumor protein p53)


Additional Information