RGD Reference Report - The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype. - Rat Genome Database

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The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype.

Authors: Barış, Savaş  Akyürek, Ömer  Dursun, Ahmet  Akyol, Mesut 
Citation: Barış S, etal., Med Clin (Barc). 2016 May 6;146(9):379-83. doi: 10.1016/j.medcli.2015.09.017. Epub 2015 Dec 3.
RGD ID: 14975256
Pubmed: PMID:26654556   (View Abstract at PubMed)
DOI: DOI:10.1016/j.medcli.2015.09.017   (Journal Full-text)


BACKGROUND AND OBJECTIVE: This trial was designed to investigate the effects of the interleukin (IL)-1β, IL-1Ra, IL-2, IL-6, IL-10 gene polymorphisms on Behcet's disease (BD) occurrence and the association between the polymorphisms and the phenotype.
MATERIALS AND METHOD: The study population consisted of 71 patients and 70 age and gender-matched healthy subjects. Each of the participants had 2cc of blood withdrawn, which was placed into a whole blood tube, and the DNA was obtained using the NucleoSpin(®) Blood DNA Isolation kit. To display the band lengths, the products were amplified using the primary pairs of the interleukins investigated and developed in a 2% agarose gel.
RESULTS: There were no significant differences between the groups with respect to the IL-1Ra, IL-1β, IL-2, IL-6 and the IL-10 gene polymorphism distributions. In the patient group the IL-1RN2 gene polymorphism was detected to be statistically correlated with the presence of articular involvement (p=0.0283) and the IL-1β gene polymorphism was statistically correlated with the presence of an ocular lesion (p=0.0178). The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution.
CONCLUSION: The statistical correlations between the articular involvement and IL-1RN, the ocular involvement and the IL-1β, and the age of disease onset and the IL-2 and IL-10 gene polymorphisms, detected for the first time in the literature, suggest that these polymorphisms could be statistically associated with the disease symptoms and used as prognostic factors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease onsetIAGP 14975256 RGD 
Behcet's disease onsetISOIL10 (Homo sapiens)14975256; 14975256 RGD 
eye disease  IAGP 14975256asociated with Behcet's diseaseRGD 
eye disease  ISOIL1B (Homo sapiens)14975256; 14975256asociated with Behcet's diseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il10  (interleukin 10)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL10  (interleukin 10)
IL1B  (interleukin 1 beta)


Additional Information