RGD Reference Report - The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype.

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The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype.
Authors:	Barış, Savaş Akyürek, Ömer Dursun, Ahmet Akyol, Mesut
Citation:	Barış S, etal., Med Clin (Barc). 2016 May 6;146(9):379-83. doi: 10.1016/j.medcli.2015.09.017. Epub 2015 Dec 3.
RGD ID:	14975256
Pubmed:	PMID:26654556 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.medcli.2015.09.017 (Journal Full-text)
BACKGROUND AND OBJECTIVE: This trial was designed to investigate the effects of the interleukin (IL)-1β, IL-1Ra, IL-2, IL-6, IL-10 gene polymorphisms on Behcet's disease (BD) occurrence and the association between the polymorphisms and the phenotype. MATERIALS AND METHOD: The study population consisted of 71 patients and 70 age and gender-matched healthy subjects. Each of the participants had 2cc of blood withdrawn, which was placed into a whole blood tube, and the DNA was obtained using the NucleoSpin(®) Blood DNA Isolation kit. To display the band lengths, the products were amplified using the primary pairs of the interleukins investigated and developed in a 2% agarose gel. RESULTS: There were no significant differences between the groups with respect to the IL-1Ra, IL-1β, IL-2, IL-6 and the IL-10 gene polymorphism distributions. In the patient group the IL-1RN2 gene polymorphism was detected to be statistically correlated with the presence of articular involvement (p=0.0283) and the IL-1β gene polymorphism was statistically correlated with the presence of an ocular lesion (p=0.0178). The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. CONCLUSION: The statistical correlations between the articular involvement and IL-1RN, the ocular involvement and the IL-1β, and the age of disease onset and the IL-2 and IL-10 gene polymorphisms, detected for the first time in the literature, suggest that these polymorphisms could be statistically associated with the disease symptoms and used as prognostic factors.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
IL10	Human	Behcet's disease	onset	IAGP			RGD
Il10	Rat	Behcet's disease	onset	ISO	IL10 (Homo sapiens)		RGD
Il10	Mouse	Behcet's disease	onset	ISO	IL10 (Homo sapiens)		RGD
IL1B	Human	eye disease		IAGP		asociated with Behcet's disease	RGD
Il1b	Rat	eye disease		ISO	IL1B (Homo sapiens)	asociated with Behcet's disease	RGD
Il1b	Mouse	eye disease		ISO	IL1B (Homo sapiens)	asociated with Behcet's disease	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il10 (interleukin 10)

Il1b (interleukin 1 beta)

Genes (Mus musculus)

Il10 (interleukin 10)

Il1b (interleukin 1 beta)

Genes (Homo sapiens)

IL10 (interleukin 10)

IL1B (interleukin 1 beta)

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The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype.