RGD Reference Report - Genetic variants of immune-related genes IL17F and IL10 are associated with functional dyspepsia: A case-control study. - Rat Genome Database

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Genetic variants of immune-related genes IL17F and IL10 are associated with functional dyspepsia: A case-control study.

Authors: Singh, Rajan  Ghoshal, Uday C  Kumar, Sushil  Mittal, Balraj 
Citation: Singh R, etal., Indian J Gastroenterol. 2017 Sep;36(5):343-352. doi: 10.1007/s12664-017-0788-7. Epub 2017 Sep 30.
RGD ID: 14975154
Pubmed: PMID:28965252   (View Abstract at PubMed)
DOI: DOI:10.1007/s12664-017-0788-7   (Journal Full-text)


BACKGROUND: Low-grade inflammation may play an important role in pathogenesis of functional dyspepsia (FD). Since cytokines may influence gastric mucosal inflammation, which is associated with FD, we evaluated singe nucleotide polymorphisms (SNPs) of pro-inflammatory IL17F and anti-inflammatory IL10 cytokine genes in patients with FD and healthy subjects (HS).
METHODS: Two hundred and thirty-seven consecutive patients with FD (Rome III) and 250 HS were genotyped for IL17F (rs2397084: A/G, rs763780: T/C) and IL10 (rs1800896: G/A, rs1800871: C/T) (PCR-RFLP).
RESULTS: Patients with FD [173 (73%) men, age 38.4±12 years] were comparable with HS [195 (78%) men, age 37.3±12 years] with respect to age and gender. Out of 237 patients, 26 (11%) had epigastric pain, 55 (23.2%) had post-prandial distress syndromes (EPS, PDS), and 156 (65.8%) had EPS-PDS overlap. Among 237 patients with FD, GG (variant) genotype of IL17F (rs2397084) was more common than HS [15 (6.3%) vs. 4 (1.6%), p=0.015, odds ratio (OR)=4.0, 95% confidence interval (CI)=1.3-12.3]. IL17F (rs763780) and IL10 (rs1800896) were comparable among patients and HS (p=0.56, 0.28), respectively. However, TT (variant) genotype of IL10 (rs1800871) was more common among patients than HS [39 (16.5%) vs. 32 (12.8%), p=0.06, OR=1.7, 95% CI=0.98-2.98]. SNPs of IL17F and IL10 (rs2397084, rs763780, rs1800896 and rs1800871) were comparable among patients among sub-types of FD (p=0.80 and 0.44).
CONCLUSION: SNPs of IL17F (rs2397084) and IL10 (rs1800871) genes are associated with FD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL10HumanDyspepsia no_associationIAGP DNA:SNP:promoter:-1082G>A (rs1800896)(human)RGD 
IL10HumanDyspepsia  IAGP DNA:SNP:promoter:-819C>A (rs1800871)(human)RGD 
Il10RatDyspepsia no_associationISOIL10 (Homo sapiens)DNA:SNP:promoter:-1082G>A (rs1800896)(human)RGD 
Il10RatDyspepsia  ISOIL10 (Homo sapiens)DNA:SNP:promoter:-819C>A (rs1800871)(human)RGD 
Il10MouseDyspepsia no_associationISOIL10 (Homo sapiens)DNA:SNP:promoter:-1082G>A (rs1800896)(human)RGD 
Il10MouseDyspepsia  ISOIL10 (Homo sapiens)DNA:SNP:promoter:-819C>A (rs1800871)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information