RGD Reference Report - Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development. - Rat Genome Database

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Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.

Authors: Hoogenraad, Casper C  Feliu-Mojer, Monica I  Spangler, Samantha A  Milstein, Aaron D  Dunah, Anthone W  Hung, Albert Y  Sheng, Morgan 
Citation: Hoogenraad CC, etal., Dev Cell. 2007 Apr;12(4):587-602. doi: 10.1016/j.devcel.2007.02.006.
RGD ID: 14696670
Pubmed: PMID:17419996   (View Abstract at PubMed)
DOI: DOI:10.1016/j.devcel.2007.02.006   (Journal Full-text)

Neural activity regulates dendrite and synapse development, but the underlying molecular mechanisms are unclear. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an important sensor of synaptic activity, and the scaffold protein liprinalpha1 is involved in pre- and postsynaptic maturation. Here we show that synaptic activity can suppress liprinalpha1 protein level by two pathways: CaMKII-mediated degradation and the ubiquitin-proteasome system. In hippocampal neurons, liprinalpha1 mutants that are immune to CaMKII degradation impair dendrite arborization, reduce spine and synapse number, and inhibit dendritic targeting of receptor tyrosine phosphatase LAR, which is important for dendrite development. Thus, regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Anapc2Ratnegative regulation of gene expression  IMP Ppfia1RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ppfia1RatSchaffer collateral - CA1 synapse is_active_inIDA PMID:17419996SynGO 
Ppfia1Ratspine apparatus is_active_inIDA PMID:17419996SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Anapc2  (anaphase promoting complex subunit 2)
Ppfia1  (PTPRF interacting protein alpha 1)


Additional Information