RGD Reference Report - Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. - Rat Genome Database

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Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover.

Authors: Körber, Christoph  Horstmann, Heinz  Venkataramani, Varun  Herrmannsdörfer, Frank  Kremer, Thomas  Kaiser, Michaela  Schwenger, Darius B  Ahmed, Saheeb  Dean, Camin  Dresbach, Thomas  Kuner, Thomas 
Citation: Körber C, etal., Neuron. 2015 Aug 5;87(3):521-33. doi: 10.1016/j.neuron.2015.07.001. Epub 2015 Jul 23.
RGD ID: 13792549
Pubmed: PMID:26212709   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2015.07.001   (Journal Full-text)

Mover, a member of the exquisitely small group of vertebrate-specific presynaptic proteins, has been discovered as an interaction partner of the scaffolding protein Bassoon, yet its function has not been elucidated. We used adeno-associated virus (AAV)-mediated shRNA expression to knock down Mover in the calyx of Held in vivo. Although spontaneous synaptic transmission remained unaffected, we found a strong increase of the evoked EPSC amplitude. The size of the readily releasable pool was unaltered, but short-term depression was accelerated and enhanced, consistent with an increase in release probability after Mover knockdown. This increase in release probability was not caused by alterations in Ca(2+) influx but rather by a higher Ca(2+) sensitivity of the release machinery, as demonstrated by presynaptic Ca(2+) uncaging. We therefore conclude that Mover expression in certain subsets of synapses negatively regulates synaptic release probability, constituting a novel mechanism to tune synaptic transmission.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tprg1lRatcalyx of Held is_active_inIDA PMID:26212709SynGO 
Tprg1lRatcalyx of Held is_active_inIMP PMID:26212709SynGO 
Tprg1lRatcalyx of Held located_inIDA PMID:26212709UniProt 
Tprg1lRatextrinsic component of synaptic vesicle membrane is_active_inIDA PMID:26212709SynGO 
Tprg1lRatglutamatergic synapse is_active_inIDA PMID:26212709SynGO 
Tprg1lRatglutamatergic synapse is_active_inIMP PMID:26212709SynGO 
BsnRatsynaptic vesicle located_inIDA PMID:26212709UniProt 
Tprg1lRatsynaptic vesicle located_inIDA PMID:26212709UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Bsn  (bassoon (presynaptic cytomatrix protein))
Tprg1l  (tumor protein p63 regulated 1-like)


Additional Information