RGD Reference Report - A third member of the synapsin gene family. - Rat Genome Database

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A third member of the synapsin gene family.

Authors: Kao, H T  Porton, B  Czernik, A J  Feng, J  Yiu, G  Häring, M  Benfenati, F  Greengard, P 
Citation: Kao HT, etal., Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4667-72.
RGD ID: 13702156
Pubmed: PMID:9539796   (View Abstract at PubMed)
PMCID: PMC22548   (View Article at PubMed Central)

Synapsins are a family of neuron-specific synaptic vesicle-associated phosphoproteins that have been implicated in synaptogenesis and in the modulation of neurotransmitter release. In mammals, distinct genes for synapsins I and II have been identified, each of which gives rise to two alternatively spliced isoforms. We have now cloned and characterized a third member of the synapsin gene family, synapsin III, from human DNA. Synapsin III gives rise to at least one protein isoform, designated synapsin IIIa, in several mammalian species. Synapsin IIIa is associated with synaptic vesicles, and its expression appears to be neuron-specific. The primary structure of synapsin IIIa conforms to the domain model previously described for the synapsin family, with domains A, C, and E exhibiting the highest degree of conservation. Synapsin IIIa contains a novel domain, termed domain J, located between domains C and E. The similarities among synapsins I, II, and III in domain organization, neuron-specific expression, and subcellular localization suggest a possible role for synapsin III in the regulation of neurotransmitter release and synaptogenesis. The human synapsin III gene is located on chromosome 22q12-13, which has been identified as a possible schizophrenia susceptibility locus. On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Syn3Ratextrinsic component of synaptic vesicle membrane is_active_inIDA PMID:9539796SynGO 
Syn3Ratextrinsic component of synaptic vesicle membrane is_active_inIEP PMID:9539796SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Syn3  (synapsin III)


Additional Information