RGD Reference Report - APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. - Rat Genome Database

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APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

Authors: Piccini, Alessandra  Castroflorio, Enrico  Valente, Pierluigi  Guarnieri, Fabrizia C  Aprile, Davide  Michetti, Caterina  Bramini, Mattia  Giansante, Giorgia  Pinto, Bruno  Savardi, Annalisa  Cesca, Fabrizia  Bachi, Angela  Cattaneo, Angela  Wren, Jonathan D  Fassio, Anna  Valtorta, Flavia  Benfenati, Fabio  Giovedì, Silvia 
Citation: Piccini A, etal., Cell Rep. 2017 Dec 19;21(12):3596-3611. doi: 10.1016/j.celrep.2017.11.073.
RGD ID: 13601995
Pubmed: PMID:29262337   (View Abstract at PubMed)
DOI: DOI:10.1016/j.celrep.2017.11.073   (Journal Full-text)

Synaptic transmission is critically dependent on synaptic vesicle (SV) recycling. Although the precise mechanisms of SV retrieval are still debated, it is widely accepted that a fundamental role is played by clathrin-mediated endocytosis, a form of endocytosis that capitalizes on the clathrin/adaptor protein complex 2 (AP2) coat and several accessory factors. Here, we show that the previously uncharacterized protein KIAA1107, predicted by bioinformatics analysis to be involved in the SV cycle, is an AP2-interacting clathrin-endocytosis protein (APache). We found that APache is highly enriched in the CNS and is associated with clathrin-coated vesicles via interaction with AP2. APache-silenced neurons exhibit a severe impairment of maturation at early developmental stages, reduced SV density, enlarged endosome-like structures, and defects in synaptic transmission, consistent with an impaired clathrin/AP2-mediated SV recycling. Our data implicate APache as an actor in the complex regulation of SV trafficking, neuronal development, and synaptic plasticity.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Btbd8RatAP-2 adaptor complex located_inIDA PMID:29262337UniProt 
Btbd8Ratneuron projection terminus located_inIDA PMID:29262337UniProt 
Btbd8Ratsynaptic vesicle located_inIDA PMID:29262337UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Btbd8  (BTB domain containing 8)


Additional Information