RGD Reference Report - Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. - Rat Genome Database

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Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure.

Authors: Ma, Jin  Ma, Shiyu  Yin, Chunxia  Wu, Huanlin 
Citation: Ma J, etal., Biomed Pharmacother. 2018 Apr;100:156-167. doi: 10.1016/j.biopha.2018.02.013. Epub 2018 Feb 8.
RGD ID: 13592597
Pubmed: PMID:29428663   (View Abstract at PubMed)
DOI: DOI:10.1016/j.biopha.2018.02.013   (Journal Full-text)


OBJECTIVE: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying mechanisms.
DESIGN AND METHODS: MI was induced by a ligation of the left anterior descending coronary artery. One week after MI surgery, FM was gavaged for 4 weeks. AF inducibility was detected by transesophageal programmed electrical stimulation technology. Multielectrode array measurements, echocardiogram, histology, and western blotting were performed.
RESULTS: The FM-treated group had lower rates of AF inducibility and shorter AF duration compared to the MI group. FM improved the conduction velocity and homogeneity, decreased left atrial positive fibrosis areas and expression of type I and III collagen, inhibited cardiac fibroblast to myofibroblast differential, and increased the expression of connexin 43 and connexin 40 in the left atrium.
CONCLUSIONS: These results suggest that FM reduced the AF inducibility after MI by improving the left atrial conduction function via inhibiting left atrial fibrosis and increasing the expression of connexin, indicating its benefit in preventing the MI-induced vulnerable substrate for AF.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GJA1Humanmyocardial infarction treatmentISOGja1 (Rattus norvegicus) RGD 
GJA5Humanmyocardial infarction treatmentISOGja5 (Rattus norvegicus) RGD 
Gja1Ratmyocardial infarction treatmentIEP  RGD 
Gja1Mousemyocardial infarction treatmentISOGja1 (Rattus norvegicus) RGD 
Gja5Ratmyocardial infarction treatmentIEP  RGD 
Gja5Mousemyocardial infarction treatmentISOGja5 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gja1  (gap junction protein, alpha 1)
Gja5  (gap junction protein, alpha 5)

Genes (Mus musculus)
Gja1  (gap junction protein, alpha 1)
Gja5  (gap junction protein, alpha 5)

Genes (Homo sapiens)
GJA1  (gap junction protein alpha 1)
GJA5  (gap junction protein alpha 5)


Additional Information