RGD Reference Report - Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). - Rat Genome Database

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Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13).

Authors: Snipes, GJ  Suter, U  Welcher, AA  Shooter, EM 
Citation: Snipes GJ, etal., J Cell Biol 1992 Apr;117(1):225-38.
RGD ID: 1358785
Pubmed: PMID:1556154   (View Abstract at PubMed)
PMCID: PMC2289391   (View Article at PubMed Central)

We have recently described a novel cDNA, SR13 (Welcher, A. A., U. Suter, M. De Leon, G. J. Snipes, and E. M. Shooter. 1991. Proc. Natl. Acad. Sci. USA. 88:7195-7199), that is repressed after sciatic nerve crush injury and shows homology to both the growth arrest-specific mRNA, gas3 (Manfioletti, G., M. E. Ruaro, G. Del Sal, L. Philipson, and C. Schneider, 1990. Mol. Cell Biol. 10:2924-2930), and to the myelin protein, PASII (Kitamura, K., M. Suzuki, and K. Uyemura. 1976. Biochim. Biophys. Acta. 455:806-816). In this report, we show that the 22-kD SR13 protein is expressed in the compact portion of essentially all myelinated fibers in the peripheral nervous system. Although SR13 mRNA was found in the central nervous system, no corresponding SR13 protein could be detected by either immunoblot analysis or by immunohistochemistry. Northern and immunoblot analysis of SR13 mRNA and protein expression during development of the peripheral nervous system reveal a pattern similar to other myelin proteins. Furthermore, we demonstrate by in situ mRNA hybridization on tissue sections and on individual nerve fibers that SR13 mRNA is produced predominantly by Schwann cells. We conclude that the SR13 protein is apparently exclusively expressed in the peripheral nervous system where it is a major component of myelin. Thus, we propose the name Peripheral Myelin Protein-22 (PMP-22) for the proteins and cDNA previously designated PASII, SR13, and gas3.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PMP22Humansciatic neuropathy  ISOPmp22 (Rattus norvegicus) RGD 
Pmp22Ratsciatic neuropathy  IEP  RGD 
Pmp22Mousesciatic neuropathy  ISOPmp22 (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pmp22Ratcompact myelin  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pmp22  (peripheral myelin protein 22)

Genes (Mus musculus)
Pmp22  (peripheral myelin protein 22)

Genes (Homo sapiens)
PMP22  (peripheral myelin protein 22)


Additional Information