RGD Reference Report - Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18. - Rat Genome Database

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Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.

Authors: Gould, KA  Tochacek, M  Schaffer, BS  Reindl, TM  Murrin, CR  Lachel, CM  VanderWoude, EA  Pennington, KL  Flood, LA  Bynote, KK  Meza, JL  Newton, MA  Shull, JD 
Citation: Gould KA, etal., Genetics 2004 Dec;168(4):2113-25.
RGD ID: 1358124
Pubmed: PMID:15611180   (View Abstract at PubMed)
PMCID: PMC1448731   (View Article at PubMed Central)
DOI: DOI:10.1534/genetics.104.033878   (Journal Full-text)

Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segregate as an incompletely dominant trait in crosses to the resistant Copenhagen (COP) strain. In both (ACI x COP)F(2) and (COP x ACI)F(2) populations, we find strong evidence for a major genetic determinant of susceptibility to E2-induced mammary cancer on distal rat chromosome 5. Our data are most consistent with a model in which the ACI allele of this locus, termed Emca1 (estrogen-induced mammary cancer 1), acts in an incompletely dominant manner to increase both tumor incidence and tumor multiplicity as well as to reduce tumor latency in these populations. We also find evidence suggestive of a second locus, Emca2, on chromosome 18 in the (ACI x COP)F(2) population. The ACI allele of Emca2 acts in a dominant manner to increase incidence and decrease latency. Together, Emca1 and Emca2 act independently to modify susceptibility to E2-induced mammary cancer.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Emca1RatExperimental Mammary Neoplasms  IDA  RGD 
Emca2RatExperimental Mammary Neoplasms  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Emca1Ratincreased mammary adenocarcinoma incidence  IAGP  RGD 
Emca2Ratincreased mammary adenocarcinoma incidence  IAGP  RGD 
Objects Annotated

QTLs
Emca1  (Estrogen-induced mammary cancer QTL 1)
Emca2  (Estrogen-induced mammary cancer QTL 2)

Strains
ACI/SegHsd  (NA)
COP/CrCrl  (NA)


Additional Information