RGD Reference Report - Multiple quantitative trait loci for blood pressure interacting epistatically and additively on dahl rat chromosome 2. - Rat Genome Database

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Multiple quantitative trait loci for blood pressure interacting epistatically and additively on dahl rat chromosome 2.

Authors: Dutil, J  Eliopoulos, V  Tremblay, J  Hamet, P  Charron, S  Deng, AY 
Citation: Dutil J, etal., Hypertension 2005 Apr;45(4):557-64. Epub 2005 Feb 28.
RGD ID: 1357413
Pubmed: PMID:15738349   (View Abstract at PubMed)
DOI: DOI:10.1161/01.HYP.0000158841.71658.5e   (Journal Full-text)

Our previous work demonstrated 2 quantitative trait loci (QTLs), C2QTL1 and C2QTL2, for blood pressure (BP) located on chromosome (Chr) 2 of Dahl salt-sensitive (DSS) rats. However, for a lack of markers, the 2 congenic strains delineating C2QTL1 and C2QTL2 could not be separated. The position of the C2QTL1 was only inferred by comparing 2 congenic strains, one having and another lacking a BP effect. Furthermore, it was not known how adjacent QTLs would interact with one another on Chr 2. In the current investigation, first, a critical chromosome marker was developed to separate 2 C2QTLs. Second, a congenic substrain was created to cover a chromosome fragment thought to harbor C2QTL1. Finally, a series of congenic strains was produced to systematically and comprehensively cover the entire Chr 2 segment containing C2QTL2 and other regions previously untested. Consequently, a total of 3 QTLs were discovered, with C2QTL3 located between C2QTL1 and C2QTL2. C2QTL1, C2QTL2, and C2QTL3 reside in chromosome segments of 5.7 centiMorgan (cM), 3.5 cM, and 1.5 cM, respectively. C2QTL1 interacted epistatically with either C2QTL2 or C2QTL3, whereas C2QTL2 and C2QTL3 showed additive effects to each other. These results suggest that BP QTLs closely linked in a segment interact epistatically and additively to one another on Chr 2.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 1357413; 1357413; 1357413 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal systemic arterial blood pressure  IAGP 1357413; 1357413; 1357413 RGD 

Objects Annotated

QTLs
Bp256  (Blood pressure QTL 256)
Bp257  (Blood pressure QTL 257)
Bp258  (Blood pressure QTL 258)

Objects referenced in this article
Marker D2Chm113 D2Chm113 Rattus norvegicus
Marker D2Chm24 D2Chm24 Rattus norvegicus
Marker D2Chm122 D2Chm122 Rattus norvegicus
Marker D2Chm46 D2Chm46 Rattus norvegicus
Marker D2Chm25 D2Chm25 Rattus norvegicus
Marker D2Chm33 D2Chm33 Rattus norvegicus
Marker D2Chm225 D2Chm225 Rattus norvegicus
Marker D2Chm57 D2Chm57 Rattus norvegicus
Marker D2Chm51 D2Chm51 Rattus norvegicus
Marker D2Chm90 D2Chm90 Rattus norvegicus
QTL Am2 Aortic mass QTL 2 Rattus norvegicus
QTL Bw179 Body weight QTL 179 Rattus norvegicus
QTL Cm85 Cardiac mass QTL 85 Rattus norvegicus
QTL Cm86 Cardiac mass QTL 86 Rattus norvegicus
QTL Kidm61 Kidney mass QTL 61 Rattus norvegicus
Strain SS.MNS-(D2Chm25-D2Mit14)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Chm25-D2Rat131)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Chm25-Fgg)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Chm51-D2Rat341)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Mit6-Adh1)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Mit6-D2Rat166)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Mit6-D2Rat303)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Rat183-D2Chm113)/Ayd null Rattus norvegicus
Strain SS.MNS-(D2Wox27-Adh1)/Ayd null Rattus norvegicus
Strain SS.MNS-(Mme-D2Mit14)/Ayd null Rattus norvegicus
Strain SS.MNS-(Mme-D2Rat131)/Ayd null Rattus norvegicus

Additional Information