RGD Reference Report - [Expression of eosinophil major basic protein mRNA in bronchial asthma]. - Rat Genome Database

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[Expression of eosinophil major basic protein mRNA in bronchial asthma].

Authors: Li, Shuang-hong  Luo, Ya-ling  Lai, Wen-yan 
Citation: Li SH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1330-3.
RGD ID: 13506941
Pubmed: PMID:16982448   (View Abstract at PubMed)


OBJECTIVE: To investigate the expression of eosinophil major basic protein (MBP) mRNA in bronchial asthma and explore its significance.
METHODS: Peripheral blood eosinophil MBP mRNA levels were measured in 40 patients with asthma and 20 normal controls by semi-quantitative RT-PCR. The association of MBP mRNA levels with eosinophil count and pulmonary function was also analyzed.
RESULTS: Compared with the normal control group, MBP mRNA level were significantly increased in asthma patients (0.37-/+0.11 vs 0.17-/+0.04, P<0.001), so was the eosinophil count (0.86-/+0.52 vs 0.21-/+0.10, P<0.001). MBP mRNA levels in patients with moderate persistent asthma (0.42-/+0.05) and those with severe persistent asthma (0.47-/+0.05) were significantly higher than those in patients with mild persistent asthma (0.25-/+0.06, P<0.001), and the difference in MBP mRNA levels between moderate persistent asthma patients and severe ones was also significant (P<0.05). Among the asthma patients, MBP mRNA levels showed an inverse correlation with pulmonary function (r=-0.7490, P<0.001).
CONCLUSION: Increased MBP mRNA expression level may correlate with the severity of asthma. MBP may play an important role in the development of asthma.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PRG2Humanasthma severityIEP mRNA:increased expression:eosinophil:RGD 
Prg2Ratasthma severityISOPRG2 (Homo sapiens)mRNA:increased expression:eosinophil:RGD 
Prg2Mouseasthma severityISOPRG2 (Homo sapiens)mRNA:increased expression:eosinophil:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prg2  (proteoglycan 2, pro eosinophil major basic protein)

Genes (Mus musculus)
Prg2  (proteoglycan 2, bone marrow)

Genes (Homo sapiens)
PRG2  (proteoglycan 2, pro eosinophil major basic protein)


Additional Information