RGD Reference Report - Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines. - Rat Genome Database

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Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines.

Authors: Tagliati, Federico  Gagliano, Teresa  Gentilin, Erica  Minoia, Mariella  Molè, Daniela  Delgi Uberti, Ettore C  Zatelli, Maria Chiara 
Citation: Tagliati F, etal., PLoS One. 2013 Sep 17;8(9):e75194. doi: 10.1371/journal.pone.0075194. eCollection 2013.
RGD ID: 13462066
Pubmed: PMID:24069394   (View Abstract at PubMed)
PMCID: PMC3775776   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0075194   (Journal Full-text)

Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line. Here we report that Magmas is highly expressed in two out of four rat pituitary adenoma cell lines and its expression levels inversely correlate to the extent of cellular response to staurosporine in terms of apoptosis activation and cell viability. Magmas over-expression in rat GH/PRL-secreting pituitary adenoma GH4C1 cells leads to an increase in cell viability and to a reduction in staurosporine-induced apoptosis and DNA fragmentation, in parallel with the increase in Magmas protein expression. These results indicate that Magmas plays a pivotal role in response to pro-apoptotic stimuli and confirm and extend the finding that Magmas protects pituitary cells from staurosporine-induced apoptosis, suggesting its possible involvement in pituitary adenoma development.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pam16Ratnegative regulation of apoptotic DNA fragmentation  IDA  RGD 
Pam16Ratnegative regulation of apoptotic process  IDA  RGD 
Pam16Ratnegative regulation of release of cytochrome c from mitochondria  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pam16  (presequence translocase associated motor 16)


Additional Information