RGD Reference Report - Cardiovascular actions of central neuromedin U in conscious rats. - Rat Genome Database

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Cardiovascular actions of central neuromedin U in conscious rats.

Authors: Chu, Chunping  Jin, Qinghua  Kunitake, Takato  Kato, Kazuo  Nabekura, Takashi  Nakazato, Masamitsu  Kangawa, Kenji  Kannan, Hiroshi 
Citation: Chu C, etal., Regul Pept. 2002 Apr 15;105(1):29-34.
RGD ID: 13461753
Pubmed: PMID:11853869   (View Abstract at PubMed)

Neuromedin U (NMU) is a brain-gut peptide, which peripherally stimulates smooth muscle, increases of blood pressure, alters ion transport in the gut, controls local blood flow, and regulates adrenocortical function. Although intracerebroventricular (i.c.v.) administration of NMU is known to decrease food intake and body weight, little is known about its effect on other physiological functions. We examined the effects of i.c.v. administration of NMU on mean arterial pressure (MAP), heart rate (HR), and plasma norepinephrine in conscious rats. Neuromedin U (0.05 and 0.5 nmol) provoked an increase in MAP (93.8 +/- 0.5 to 123.5 +/- 1.7 and 94.7 +/- 0.8 to 132.7 +/- 3.0 mm Hg, respectively) and HR (334.9 +/- 6.0 to 494.1 +/- 6.9 and 346.3 +/- 3.3 to 475.1 +/- 8.9 beats/min, respectively). In contrast, plasma norepinephrine increased only with a high dose of neuromedin U. Intravenously administered NMU (0.5 nmol) elicited a small and short lasting increase in MAP, compared to that by i.c.v. NMU. These results indicate that central neuromedin U regulates sympathetic nervous system activity and affects cardiovascular function.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NmuRatpositive regulation of heart rate involved_inIDA PMID:11853869UniProt 
NmuRatpositive regulation of systemic arterial blood pressure involved_inIDA PMID:11853869UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Nmu  (neuromedin U)


Additional Information