RGD Reference Report - The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure. - Rat Genome Database

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The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure.

Authors: Okamoto, Ken-Ichi  Narayanan, Radhakrishnan  Lee, Sang H  Murata, Kazuyoshi  Hayashi, Yasunori 
Citation: Okamoto K, etal., Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6418-23. Epub 2007 Apr 2.
RGD ID: 13432239
Pubmed: PMID:17404223   (View Abstract at PubMed)
PMCID: PMC1851051   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0701656104   (Journal Full-text)

Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase critically involved in synaptic plasticity in the brain. It is highly concentrated in the postsynaptic density fraction, exceeding the amount of any other signal transduction molecules. Because kinase signaling can be amplified by catalytic reaction, why CaMKII exists in such a large quantity has been a mystery. Here, we provide biochemical evidence that CaMKII is capable of bundling F-actin through a stoichiometric interaction. Consistent with this evidence, in hippocampal neurons, RNAi-mediated down-regulation of CaMKII leads to a reduction in the volume of dendritic spine head that is mediated by F-actin dynamics. An overexpression of CaMKII slowed down the actin turnover in the spine head. This activity was associated with beta subunit of CaMKII in a manner requiring its actin-binding and association domains but not the kinase domain. This finding indicates that CaMKII serves as a central signaling molecule in both functional and structural changes during synaptic plasticity.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Camk2bRatregulation of synapse maturation involved_inIDA PMID:17404223SynGO 
Camk2bRatregulation of synapse maturation involved_inIEP PMID:17404223SynGO 
Camk2bRatregulation of synapse maturation involved_inIMP PMID:17404223SynGO 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Camk2bRatglutamatergic synapse is_active_inIDA PMID:17404223SynGO 
Camk2bRatglutamatergic synapse is_active_inIEP PMID:17404223SynGO 
Camk2bRatglutamatergic synapse is_active_inIMP PMID:17404223SynGO 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Camk2b  (calcium/calmodulin-dependent protein kinase II beta)


Additional Information