RGD Reference Report - The hypertriglyceridemic rat as a genetic model of hypertension and diabetes. - Rat Genome Database

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The hypertriglyceridemic rat as a genetic model of hypertension and diabetes.

Authors: Stolba, P  Dobesova, Z  Husek, P  Opltova, H  Zicha, J  Vrana, A  Kunes, J 
Citation: Stolba P, etal., Life Sci 1992;51(10):733-40.
RGD ID: 1342424
Pubmed: PMID:1513201   (View Abstract at PubMed)

Hypertriglyceridemia was demonstrated in untreated hypertensive patients as well as in animals with genetic and experimental hypertension. The main purpose of the present study was to evaluate the possibility to use the hereditary hypertriglyceridemic (HTG) nonobese rats in hypertensive research. Direct measurement of blood pressure demonstrated significantly higher systolic, diastolic and mean arterial pressures in HTG rats in comparison with control Wistar rats. There was significant positive correlation between blood pressure and plasma triglyceride concentration (r = 0.585, n = 40, p less than 0.001). In addition, there were significantly increased plasma norepinephrine and epinephrine concentrations in HTG rats, suggesting that the stimulation of sympathetic nervous system could be one of the pathogenetic mechanisms involved in the increase of blood pressure of HTG rats.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HTGRatdecreased body weight  IAGP compared to WistarRGD 
HTGRatimproved glucose tolerance  IAGP compared to WistarRGD 
HTGRatincreased circulating adrenaline level  IAGP compared to WistarRGD 
HTGRatincreased circulating free fatty acids level  IAGP compared to WistarRGD 
HTGRatincreased circulating noradrenaline level  IAGP compared to WistarRGD 
HTGRatincreased circulating triglyceride level  IAGP compared to WistarRGD 
HTGRatincreased glycosylated hemoglobin level  IAGP compared to WistarRGD 
HTGRatincreased mean systemic arterial blood pressure  IAGP compared to WistarRGD 
HTGRatincreased systemic arterial diastolic blood pressure  IAGP compared to WistarRGD 
HTGRatincreased systemic arterial systolic blood pressure  IAGP compared to WistarRGD 
HTGRatinsulin resistance  IAGP compared to WistarRGD 
Objects Annotated

Strains
HTG  (Prague hypertriglyceridemic)


Additional Information