RGD Reference Report - Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta. - Rat Genome Database

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Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta.

Authors: Gauguier, D  Behmoaras, J  Argoud, K  Wilder, SP  Pradines, C  Bihoreau, MT  Osborne-Pellegrin, M  Jacob, MP 
Citation: Gauguier D, etal., Hypertension 2005 Jan 24;.
RGD ID: 1334448
Pubmed: PMID:15668357   (View Abstract at PubMed)
DOI: DOI:10.1161/01.HYP.0000155213.83719.7c   (Journal Full-text)

Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. In addition to its structural role, elastin is a regulator that maintains homeostasis through biologic signaling. Genetically determined minor modifications in elastin and collagen in the aorta could influence the onset and evolution of arterial pathology, such as hypertension and its complications. We previously demonstrated that the inbred Brown Norway (BN) rat shows an aortic elastin deficit in both abdominal and thoracic segments, partly because of a decrease in tropoelastin synthesis when compared with the LOU rat, that elastin gene polymorphisms in these strains do not significantly account for. After a genome-wide search for quantitative trait loci (QTL) influencing the aortic elastin, collagen, and cell protein contents in an F2 population derived from BN and LOU rats, we identified on chromosomes 2 and 14, 3 QTL specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. We also mapped 3 highly significant QTL linked to body weight (on chromosomes 1 and 3) and heart weight (on chromosome 1) in the cross. This study demonstrates the polygenic control of the content of key components of the arterial wall. Such information represents a first step in understanding possible mechanisms involved in dysregulation of these parameters in arterial pathology.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cardiomegaly  IAGP 1334448 RGD 
cardiovascular system disease  IAGP 1334448; 1334448; 1334448; 1334448 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Ael1  (Aortic elastin QTL 1)
Ael2  (Aortic elastin QTL 2)
Ael3  (Aortic elastin QTL 3)
Aocep1  (Aortic cell protein QTL 1)
Bw37  (Body weight QTL 37)
Bw38  (Body weight QTL 38)
Cm37  (Cardiac mass QTL 37)

BN  (BN)
LOU/Ins  (NA)

Objects referenced in this article
Marker D3Wox33 D3Wox33 Rattus norvegicus

Additional Information