RGD Reference Report - The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. - Rat Genome Database

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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

Authors: Ciechanover, A  Brundin, P 
Citation: Ciechanover A and Brundin P, Neuron 2003 Oct 9;40(2):427-46.
RGD ID: 1302872
Pubmed: PMID:14556719   (View Abstract at PubMed)

The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin-interacting and -associated motifs modulate many others. This tightly controlled process involves multiple specific and general enzymes of the system as well as many modifying and ancillary proteins. Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular processes. Moreover, aberrations in the system have been implicated, either as a primary cause or secondary consequence, in the pathogenesis of both inherited and acquired neurodegenerative diseases. Recent findings indicate that the system is involved in the pathogenesis of Parkinson's, Alzheimer's, Huntington's, and Prion diseases as well as amyotrophic lateral sclerosis. This raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the development of novel, mechanism-based therapeutic modalities.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Snca  (synuclein alpha)

Genes (Homo sapiens)
PRKN  (parkin RBR E3 ubiquitin protein ligase)
SNCA  (synuclein alpha)

Objects referenced in this article
Gene UCHL1 ubiquitin C-terminal hydrolase L1 Homo sapiens
Gene Prkn parkin RBR E3 ubiquitin protein ligase Mus musculus
Gene Uchl1 ubiquitin C-terminal hydrolase L1 Rattus norvegicus

Additional Information